Department of Epidemiology and Health Promotion, Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul 03722, Korea.
Department of Public Health, Graduate School, Yonsei University, Seoul 03722, Korea.
Int J Environ Res Public Health. 2022 Jul 18;19(14):8745. doi: 10.3390/ijerph19148745.
Epidemiological studies have inconsistently shown an association between dioxin and risk of type 2 diabetes mellitus (T2DM) and cancer. This study aims to examine the effects of blood concentration of dioxin-like polychlorinated biphenyls (DL-PCBs) and polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/DFs) on T2DM and thyroid cancer.
We conducted a nested case-control study within the Korean cancer prevention study-II (KCPS-II) consisting of 15 thyroid cancer cases, 30 T2DM cases, and 55 controls. A total of 500 samples were used in 100 pooling samples. An average value of a pooled sample was calculated weighted by the blood volume of each sample.
The study population included 100 participants from the KCPS-II (median (IQR) baseline age, 54.06 [21.04] years; 48 women). The toxic equivalents of PCDD/DFs showed a significant positive association with T2DM and thyroid cancer, after adjustments for potential confounders (T2DM ORs = 1.23; 95% CI = 1.05-1.43; thyroid cancer ORs = 1.34; 95% CI = 1.12-1.61).
In this study, both T2DM and thyroid cancer were associated with the blood concentrations of PCDD/DFs. The association between PCDD/DFs and T2D was found among women but not among men. Our findings suggest that further biochemical in vivo research and epidemiologic studies are needed to clarify the association between dioxins concentrations and diseases.
流行病学研究表明，二恶英与 2 型糖尿病（T2DM）和癌症风险之间存在关联，但结果并不一致。本研究旨在探讨血中二恶英样多氯联苯（DL-PCBs）和多氯二苯并对二恶英和二苯并呋喃（PCDD/DFs）浓度与 T2DM 和甲状腺癌的关系。
我们在韩国癌症预防研究 II（KCPS-II）中进行了一项巢式病例对照研究，该研究包括 15 例甲状腺癌病例、30 例 T2DM 病例和 55 例对照。共使用了 500 个样本，100 个样本进行了混合。混合样本的平均值按每个样本的血量进行加权。
该研究人群包括来自 KCPS-II 的 100 名参与者（中位（IQR）基线年龄为 54.06[21.04]岁；48 名女性）。调整潜在混杂因素后，PCDD/DF 的毒性当量与 T2DM 和甲状腺癌呈显著正相关（T2DM ORs = 1.23；95%CI = 1.05-1.43；甲状腺癌 ORs = 1.34；95%CI = 1.12-1.61）。
在这项研究中，T2DM 和甲状腺癌均与 PCDD/DFs 的血浓度相关。PCDD/DFs 与 T2D 的关联仅在女性中存在，而在男性中不存在。我们的研究结果表明，需要进一步进行体内生化研究和流行病学研究，以阐明二恶英浓度与疾病之间的关系。
Zotero 插件
