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以鼻内催产素治疗创伤后应激障碍为例的个性化精神治疗进展。

Progress in Personalized Psychiatric Therapy with the Example of Using Intranasal Oxytocin in PTSD Treatment.

作者信息

Szafoni Sandra, Piegza Magdalena

机构信息

Department of Psychiatry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, 42-612 Tarnowskie Góry, Poland.

出版信息

J Pers Med. 2022 Jun 29;12(7):1067. doi: 10.3390/jpm12071067.

DOI:10.3390/jpm12071067
PMID:35887564
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9317706/
Abstract

Post-traumatic stress disorder (PTSD) is a severe mental disorder that results in the frequent coexistence of other diseases, lowers patients' quality of life, and has a high annual cost of treatment. However, despite the variety of therapeutic approaches that exist, some patients still do not achieve the desired results. In addition, we may soon face an increase in the number of new PTSD cases because of the current global situation-both the COVID-19 pandemic and the ongoing armed conflicts. Hence, in recent years, many publications have sought a new, more personalized treatment approach. One such approach is the administration of intranasal oxytocin (INOXT), which, due to its pleiotropic effects, seems to be a promising therapeutic option. However, the current findings suggest that it might only be helpful for a limited, strictly selected group of patients.

摘要

创伤后应激障碍(PTSD)是一种严重的精神障碍,常伴有其他疾病,会降低患者的生活质量,且每年的治疗费用高昂。然而,尽管现有多种治疗方法,但仍有一些患者未取得理想疗效。此外,鉴于当前的全球形势——新冠疫情和持续的武装冲突,我们可能很快会面临新的创伤后应激障碍病例数增加的情况。因此,近年来,许多出版物都在寻求一种新的、更个性化的治疗方法。其中一种方法是鼻内给予催产素(INOXT),由于其具有多效性,似乎是一种有前景的治疗选择。然而,目前的研究结果表明,它可能仅对有限的、经过严格筛选的患者群体有帮助。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0be2/9317706/73af231dd1ac/jpm-12-01067-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0be2/9317706/fe53c82fbe2b/jpm-12-01067-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0be2/9317706/f6841ddc5ce9/jpm-12-01067-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0be2/9317706/73af231dd1ac/jpm-12-01067-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0be2/9317706/fe53c82fbe2b/jpm-12-01067-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0be2/9317706/f6841ddc5ce9/jpm-12-01067-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0be2/9317706/73af231dd1ac/jpm-12-01067-g003.jpg

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Psychiatr Pol. 2022 Aug 31;56(4):823-836. doi: 10.12740/PP/OnlineFirst/133919.
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Association of depression and COVID-induced PTSD with cognitive symptoms after COVID-19 illness.新冠肺炎后抑郁和 COVID-19 所致创伤后应激障碍与认知症状的关联。
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COVID-19 induced PTSD: Stressors for trauma and acute care surgeons.
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Neuropharmacology. 2023 Mar 15;226:109418. doi: 10.1016/j.neuropharm.2023.109418. Epub 2023 Jan 6.
COVID-19 所致创伤后应激障碍:创伤和急症外科医生的应激源。
Am J Surg. 2022 Sep;224(3):843-848. doi: 10.1016/j.amjsurg.2022.02.060. Epub 2022 Mar 4.
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Healthcare Workers and COVID-19-Related Moral Injury: An Interpersonally-Focused Approach Informed by PTSD.医护人员与新冠疫情相关的道德伤害:一种受创伤后应激障碍启发的以人际关系为重点的方法
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