Pagkratis Nikolaos, Matsagas Miltiadis, Malli Foteini, Gourgoulianis Konstantinos I, Kotsiou Ourania S
Psychiatric Clinic, General Hospital of Corfu, 49100 Corfu, Greece.
Department of Respiratory Medicine, Faculty of Medicine, University of Thessaly, 41110 Larissa, Greece.
J Pers Med. 2022 Jul 13;12(7):1133. doi: 10.3390/jpm12071133.
The prevalence of anticoagulant therapy-associated hemorrhagic complications in hospitalized patients with pulmonary embolism (PE) has been scarcely investigated.
To evaluate the prevalence of hemorrhages in hospitalized PE patients.
The Information System "ASKLIPIOS™ HOSPITAL" implemented in the Respiratory Medicine Department, University of Thessaly, was used to collect demographic, clinical and outcome data from January 2013 to April 2021.
326 patients were included. Males outnumbered females. The population's mean age was 68.7 ± 17.0 years. The majority received low molecular weight heparin (LMWH). Only 5% received direct oral anticoagulants. 15% of the population were complicated with hemorrhage, of whom 18.4% experienced a major event. Major hemorrhages were fewer than minor (29.8% vs. 70.2%, = 0.001). Nadroparin related to 83.3% of the major events. Hematuria was the most common hemorrhagic event. 22% of patients with major events received a transfusion, and 11% were admitted to intensive care unit (ICU). The events lasted for 3 ± 2 days. No death was recorded.
1/5 of the patients hospitalized for PE complicated with hemorrhage without a fatal outcome. The hemorrhages were mainly minor and lasted for 3 ± 2 days. Among LMWHs, nadroparin was related to a higher percentage of hemorrhages.
住院肺栓塞（PE）患者中抗凝治疗相关出血并发症的患病率鲜有研究。
评估住院PE患者出血的患病率。
使用在色萨利大学呼吸内科实施的“ASKLIPIOS™医院信息系统”收集2013年1月至2021年4月的人口统计学、临床和结局数据。
纳入326例患者。男性多于女性。人群平均年龄为68.7±17.0岁。大多数患者接受低分子肝素（LMWH）治疗。仅5%的患者接受直接口服抗凝剂治疗。15%的患者并发出血，其中18.4%发生严重事件。严重出血少于轻微出血（29.8%对70.2%，P = 0.001）。那屈肝素与83.3%的严重事件相关。血尿是最常见的出血事件。22%发生严重事件的患者接受了输血，11%入住重症监护病房（ICU）。这些事件持续3±2天。无死亡记录。
1/5的住院PE患者并发出血且无致命结局。出血主要为轻微出血，持续3±2天。在低分子肝素中，那屈肝素与更高比例的出血相关。
