Jeon Jin Pyeong, Han Sung Woo, Kim Tae Yeon, Lim Seung Hyuk, Youn Dong Hyuk, Rhim Jong Kook, Park Jeong Jin, Ahn Jun Hyong, Kim Heung Cheol, Yang Jinseo
Department of Neurosurgery, Hallym University College of Medicine, Chuncheon 24253, Korea.
Institute of New Frontier Research, Hallym University College of Medicine, Chuncheon 24253, Korea.
Life (Basel). 2022 Jul 6;12(7):1001. doi: 10.3390/life12071001.
We aimed to investigate the association of Haptoglobin (Hp) phenotypes with perihematomal edema (PHE) and neurological outcomes after intracerebral hemorrhage (ICH).
This prospective multicenter study enrolled patients that suffered ICH from March 2017 to February 2020. Hp phenotypes were determined using Western blotting; relative α1 intensity was calculated in patients with Hp2-1. A multivariable logistic regression analysis was then conducted to identify risk factors for increased relative PHE at 96 h and 3-month poor outcomes.
In total, 120 patients were ultimately enrolled: Hp1-1 (n = 15, 12.5%); Hp2-1 (n = 51, 42.5%); and Hp2-2 (n = 54, 45.0%). Hp phenotype was significantly associated with PHE ( = 0.028). With Hp1-1 as a reference value, Hp2-2 significantly increased the likelihood of increased rPHE (OR = 6.294, 95% CI: 1.283-30.881), while Hp2-1 did not (OR = 2.843, 95% CI: 0.566-14.284). Poor outcomes were found to be closely associated with hematoma volume at admission (OR = 1.057, 95% CI: 1.015-1.101) and surgical treatment (OR = 5.340, 95% CI: 1.665-17.122) but not Hp phenotypes ( = 0.190). Further, a high level of relative α1 intensity was identified to be significantly associated with decreased rPHE (OR = 0.020, 95% CI: 0.001-0.358). However, the relative α1 intensity was not associated with poor outcomes (OR = 0.057, 95% CI: 0.001-11.790).
ICH patients with Hp2-2 exhibited a higher likelihood of increased rPHE than those with Hp1-1. Higher relative α1 intensities were identified to be closely associated with rPHE in patients with Hp2-1.
我们旨在研究血红素结合蛋白（Hp）表型与脑出血（ICH）后血肿周围水肿（PHE）及神经功能结局之间的关联。
这项前瞻性多中心研究纳入了2017年3月至2020年2月期间发生ICH的患者。采用蛋白质印迹法测定Hp表型；计算Hp2-1患者的相对α1强度。然后进行多变量逻辑回归分析，以确定96小时时相对PHE增加及3个月时预后不良的危险因素。
最终共纳入120例患者：Hp1-1（n = 15，12.5%）；Hp2-1（n = 51，42.5%）；Hp2-2（n = 54，45.0%）。Hp表型与PHE显著相关（P = 0.028）。以Hp1-1作为参考值，Hp2-2显著增加了rPHE升高的可能性（OR = 6.294，95%CI：1.283 - 30.881），而Hp2-1则未增加（OR = 2.843，95%CI：0.566 - 14.284）。发现预后不良与入院时血肿体积（OR = 1.057，95%CI：1.015 - 1.101）及手术治疗（OR = 5.340，95%CI：1.665 - 17.122）密切相关，但与Hp表型无关（P = 0.190）。此外，高水平的相对α1强度被确定与rPHE降低显著相关（OR = 0.020，95%CI：0.001 - 0.358）。然而，相对α1强度与预后不良无关（OR = 0.057，9%CI：0.001 - 11.790）。
与Hp1-1的ICH患者相比，Hp2-2的ICH患者rPHE升高的可能性更高。在Hp2-1患者中，较高的相对α1强度与rPHE密切相关。
