Balgrist Campus, University of Zurich, Lengghalde 5, 8008 Zurich, Switzerland.
Institute of Anesthesiology, Triemli City Hospital, 8063 Zurich, Switzerland.
Medicina (Kaunas). 2022 Jun 30;58(7):882. doi: 10.3390/medicina58070882.
There is a growing interest regarding the impact of the perioperative period and the application of anesthetic drugs on the recurrence of cancer metastases. Among them, the use of amide-type local anesthetics seems promising since in vitro studies and animal models have shown their potential to inhibit the Intercellular Adhesion Molecule 1 (ICAM-1) expression and Src activity, which are clearly implicated in the process of inflammation and cancer metastases. This review emphasizes the potential of amide-type local anesthetics in this context.
人们越来越关注围手术期和麻醉药物的应用对癌症转移复发的影响。酰胺类局麻药的应用似乎很有前景，因为体外研究和动物模型表明其具有抑制细胞间黏附分子 1（ICAM-1）表达和Src 活性的潜力，而这两者显然与炎症和癌症转移过程有关。本文强调了酰胺类局麻药在这方面的潜力。
