Salvatore Michele Antonio, Corsi Decenti Edoardo, Bonasoni Maria Paola, Botta Giovanni, Castiglione Francesca, D'Armiento Maria, Fulcheri Ezio, Nebuloni Manuela, Donati Serena
National Centre for Disease Prevention and Health Promotion, Istituto Superiore di Sanità-Italian National Institute of Health, Viale Regina Elena 299, 00161 Rome, Italy.
Department of Biomedicine and Prevention, University of Rome Tor Vergata, Viale Montpellier 1, 00133 Rome, Italy.
Microorganisms. 2022 Jul 15;10(7):1435. doi: 10.3390/microorganisms10071435.
The variety of placental morphological findings with SARS-CoV-2 maternal infections has raised the issue of poor agreement in histopathological evaluation. The aims of this study were: to describe the histopathological placental features of a large sample of SARS-CoV-2-positive women who gave birth in Italy during the COVID-19 pandemic, to analyse the factors underlying these lesions, and to analyse the impact of placental impairment on perinatal outcomes. From 25 February 2020 to 30 June 2021, experienced perinatal pathologists examined 975 placentas of SARS-CoV-2-positive mothers enrolled in a national prospective study, adopting the Amsterdam Consensus Statement protocol. The main results included the absence of specific pathological findings for SARS-CoV-2 infections, even though a high proportion of placentas showed signs of inflammation, possibly related to a cytokine storm induced by the virus, without significant perinatal consequences. Further research is needed to better define the clinical implications of placental morphology in SARS-CoV-2 infections, but the results of this large cohort suggest that placentas do not seem to be a preferential target for the new Coronavirus infection.
新型冠状病毒肺炎（COVID-19）大流行期间，意大利SARS-CoV-2感染孕产妇的胎盘形态学表现多样，引发了组织病理学评估一致性差的问题。本研究的目的是：描述COVID-19大流行期间在意大利分娩的大量SARS-CoV-2阳性女性的胎盘组织病理学特征，分析这些病变的潜在因素，并分析胎盘损伤对围产期结局的影响。从2020年2月25日至2021年6月30日，经验丰富的围产期病理学家采用阿姆斯特丹共识声明方案，对纳入一项全国前瞻性研究的975例SARS-CoV-2阳性母亲的胎盘进行了检查。主要结果包括未发现SARS-CoV-2感染的特异性病理表现，尽管高比例的胎盘显示有炎症迹象，可能与病毒诱导的细胞因子风暴有关，但对围产期无显著影响。需要进一步研究以更好地确定胎盘形态在SARS-CoV-2感染中的临床意义，但这个大型队列的结果表明，胎盘似乎不是新型冠状病毒感染的优先靶器官。
