Department of Medicinal Chemistry, Collegium Medicum in Bydgoszcz, Faculty of Pharmacy, Nicolaus Copernicus University in Torun, Dr. A. Jurasza 2, 85-089 Bydgoszcz, Poland.
Institute of Chemistry and Technical Electrochemistry, Poznan University of Technology, Berdychowo 4, 60-965 Poznan, Poland.
Molecules. 2022 Jul 9;27(14):4409. doi: 10.3390/molecules27144409.
A sulfanyl porphyrazine derivative with peripheral phthalimide moieties was metallated with cobalt(II) and iron(II) metal ions. The purity of the macrocycles was confirmed by HPLC, and subsequently, compounds were characterized using various analytical methods (ES-TOF, MALDI-TOF, UV-VIS, and NMR spectroscopy). To obtain hybrid electroactive electrode materials, novel porphyrazines were combined with multiwalled carbon nanotubes. The electrocatalytic effect derived from cobalt(II) and iron(II) cations was evaluated. As a result, a significant decrease in the overpotential was observed compared with that obtained with bare glassy carbon (GC) or glassy carbon electrode/carbon nanotubes (GC/MWCNTs), which allowed for sensitive determination of hydrogen peroxide in neutral conditions (pH 7.4). The prepared sensor enables a linear response to HO concentrations of 1-90 µM. A low detection limit of 0.18 μM and a high sensitivity of 640 μA mM cm were obtained. These results indicate that the obtained sensors could potentially be applied in biomedical and environmental fields.
具有外围邻苯二甲酰亚胺部分的硫代卟啉嗪衍生物与钴（II）和铁（II）金属离子配位。通过 HPLC 确认大环的纯度，随后使用各种分析方法（ES-TOF、MALDI-TOF、UV-VIS 和 NMR 光谱）对化合物进行表征。为了获得混合电活性电极材料，将新型卟啉与多壁碳纳米管结合。评估了钴（II）和铁（II）阳离子的电催化效应。结果表明，与裸玻碳（GC）或玻碳电极/碳纳米管（GC/MWCNTs）相比，过电位显著降低，这使得在中性条件（pH 7.4）下能够灵敏地测定过氧化氢。制备的传感器对 HO 的线性响应浓度为 1-90 µM。获得了 0.18 μM 的低检测限和 640 μA mM cm 的高灵敏度。这些结果表明，所获得的传感器有可能应用于生物医学和环境领域。
