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母体高脂肪饮食会减少 2 型神经干细胞，并促进早期产后发育过程中的过早神经元分化。

Maternal High-Fat Diet Reduces Type-2 Neural Stem Cells and Promotes Premature Neuronal Differentiation during Early Postnatal Development.

机构信息

Department/Institute of Neurobiology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.

Key Laboratory of Ministry of Education for Environment and Genes Related to Diseases, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.

出版信息

Nutrients. 2022 Jul 8;14(14):2813. doi: 10.3390/nu14142813.

DOI:10.3390/nu14142813
PMID:35889772
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9316544/
Abstract

Maternal obesity or exposure to a high-fat diet (HFD) has an irreversible impact on the structural and functional development of offspring brains. This study aimed to investigate whether maternal HFD during pregnancy and lactation impairs dentate gyrus (DG) neurogenesis in offspring by altering neural stem cells (NSCs) behaviors. Pregnant Sprague-Dawley rats were fed a chow diet (CHD) or HFD (60% fat) during gestation and lactation. Pups were collected on postnatal day 1 (PND 1), PND 10 and PND 21. Changes in offspring body weight, brain structure and granular cell layer (GCL) thickness in the hippocampus were analyzed. Hippocampal NSCs behaviors, in terms of proliferation and differentiation, were investigated after immunohistochemical staining with Nestin, Ki67, SOX2, Doublecortin (DCX) and NeuN. Maternal HFD accelerated body weight gain and brain structural development in offspring after birth. It also reduced the number of NSCs and their proliferation, leading to a decrease in NSCs pool size. Furthermore, maternal HFD intensified NSCs depletion and promoted neuronal differentiation in the early postnatal development period. These findings suggest that maternal HFD intake significantly reduced the amount and capability of NSCs via reducing type-2 NSCs and promoting premature neuronal differentiation during postnatal hippocampal development.

摘要

母体肥胖或暴露于高脂肪饮食（HFD）会对后代大脑的结构和功能发育产生不可逆的影响。本研究旨在探讨母体在妊娠和哺乳期摄入 HFD 是否通过改变神经干细胞（NSCs）行为来损害后代齿状回（DG）的神经发生。妊娠 Sprague-Dawley 大鼠在妊娠和哺乳期分别给予标准饮食（CHD）或 HFD（60%脂肪）。在产后第 1 天（PND1）、第 10 天（PND10）和第 21 天（PND21）收集幼崽。分析后代体重、大脑结构和海马颗粒细胞层（GCL）厚度的变化。通过巢蛋白、Ki67、SOX2、双皮质素（DCX）和 NeuN 的免疫组织化学染色，研究海马 NSCs 的增殖和分化行为。母体 HFD 在出生后加速了后代体重增加和大脑结构发育。它还减少了 NSCs 的数量及其增殖，导致 NSCs 池大小减少。此外，母体 HFD 在产后早期发育阶段加剧了 NSCs 的耗竭并促进了神经元分化。这些发现表明，母体 HFD 摄入通过减少 2 型 NSCs 并促进产后海马发育过程中的过早神经元分化，显著降低了 NSCs 的数量和功能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bbc/9316544/cd8ce6c017fa/nutrients-14-02813-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bbc/9316544/a2cd05d45006/nutrients-14-02813-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bbc/9316544/b3b3dad0cf67/nutrients-14-02813-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bbc/9316544/b2f4110c5e30/nutrients-14-02813-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bbc/9316544/1cb77a37e3e2/nutrients-14-02813-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bbc/9316544/7bd8550370de/nutrients-14-02813-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bbc/9316544/cd8ce6c017fa/nutrients-14-02813-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bbc/9316544/a2cd05d45006/nutrients-14-02813-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bbc/9316544/b3b3dad0cf67/nutrients-14-02813-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bbc/9316544/b2f4110c5e30/nutrients-14-02813-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bbc/9316544/1cb77a37e3e2/nutrients-14-02813-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bbc/9316544/7bd8550370de/nutrients-14-02813-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bbc/9316544/cd8ce6c017fa/nutrients-14-02813-g006.jpg

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3
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4
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6
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