Department of Preventive Medicine and Public Health, University of Granada, 18016 Granada, Spain.
Instituto de Investigación Biosanitaria (ibs.GRANADA), 18014 Granada, Spain.
Nutrients. 2022 Jul 21;14(14):2991. doi: 10.3390/nu14142991.
Lifestyle changes are causing an exponential increase in the prevalence of obesity and metabolic syndrome (MetS) worldwide. The most frequent complications of these are the development of diabetes (T2D) and cardiovascular disease (CVD). Accurate tools are needed to classify the cardiovascular risk (CVR) in the MetS population. In recent years, numerous biomarkers of bone metabolism have been associated with CVR. The aim of this study was to determine the levels of undercarboxylated osteocalcin (ucOC) in a cohort of patients with MetS and to analyse its association with MetS parameters and CVR as well as with T2D prevalence. A longitudinal study was conducted in which a MetS population was followed for one year. Weight change, adherence to the Mediterranean diet (MedDiet), ucOC levels, MetS parameters and CVR were analysed and CVR was calculated using different scores. Our results showed a decrease of CVR associated with a better adherence to the MetDiet resulting in higher HDL-C and ucOC levels though the improvement of MetS risk factors. This bone protein appeared as a potential biomarker to classify CVR in the MetS population, especially for MetS patients without prevalent T2D. Furthermore, ucOC serum levels could be good predictors of T2D prevalence.
生活方式的改变正在导致肥胖和代谢综合征（MetS）在全球范围内的患病率呈指数级增长。这些疾病最常见的并发症是糖尿病（T2D）和心血管疾病（CVD）的发展。需要准确的工具来对 MetS 人群的心血管风险（CVR）进行分类。近年来，许多骨代谢生物标志物与 CVR 相关。本研究的目的是确定代谢综合征患者队列中的非羧化骨钙素（ucOC）水平，并分析其与 MetS 参数和 CVR 以及 T2D 患病率的关系。进行了一项纵向研究，对代谢综合征人群进行了一年的随访。分析了体重变化、地中海饮食（MedDiet）的依从性、ucOC 水平、MetS 参数和 CVR，并使用不同的评分计算了 CVR。我们的结果表明，与更好地遵循 MetDiet 相关的 CVR 降低，导致 HDL-C 和 ucOC 水平升高，尽管 MetS 风险因素有所改善。这种骨蛋白似乎是 MetS 人群中分类 CVR 的潜在生物标志物，尤其是对于没有普遍存在 T2D 的 MetS 患者。此外，ucOC 血清水平可能是 T2D 患病率的良好预测指标。
