Ernholm Linda, Sternberg-Lewerin Susanna, Ågren Erik, Ståhl Karl, Hultén Cecilia
Department of Biomedical Sciences and Veterinary Public Health, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences (SLU), SE-750 07 Uppsala, Sweden.
Department of Disease Control and Epidemiology, National Veterinary Institute (SVA), SE-751 89 Uppsala, Sweden.
Pathogens. 2022 Jun 24;11(7):723. doi: 10.3390/pathogens11070723.
Following the first detection of subsp. , serovar Choleraesuis (. Choleraesuis) in a Swedish pig herd for more than 40 years and subsequent detection of the same serotype in an enclosure with kept wild boar, a national surveillance for Choleraesuis in free living wild boar was launched. A total of 633 wild boar sampled within the active and the enhanced passive surveillance were examined for serovars by culture. Of these, 80 animals were culture positive for . Choleraesuis var. Kunzendorf. All positive animals, including those in the original outbreaks, originated from counties located in the southern and eastern parts of Sweden. Fifty-eight isolates were selected for sequence typing, revealing a relatively homogenous population of . Choleraesuis with two distinct genetic clusters containing isolates from the southern counties in one and the counties further northeast in the other. Sequenced isolates from domestic pig farms all clustered with wild boar in the same region. Choleraesuis appears highly contagious in dense wild boar populations, making it a relevant model for other infectious diseases that may be transmitted to pigs. The many potential routes of introduction and spread of . Choleraesuis warrant further investigations in order to prepare for other disease threats.
在瑞典猪群中首次检测到猪霍乱沙门氏菌猪霍乱亚种（Salmonella Choleraesuis subsp. Choleraesuis）40多年后，又在一个圈养野猪的围栏中检测到相同血清型，随后启动了对自由生活野猪中猪霍乱沙门氏菌的全国监测。通过培养对在主动监测和强化被动监测中采集的总共633头野猪进行了猪霍乱沙门氏菌血清型检测。其中，80头动物的猪霍乱沙门氏菌Kunzendorf变种培养呈阳性。所有阳性动物，包括最初疫情中的动物，均来自瑞典南部和东部的县。选择了58株分离株进行序列分型，结果显示猪霍乱沙门氏菌群体相对同质，有两个不同的基因簇，一个包含来自南部县的分离株，另一个包含更东北部县的分离株。来自国内猪场的测序分离株均与同一地区的野猪聚集在一起。猪霍乱沙门氏菌在密集的野猪种群中似乎具有高度传染性，使其成为可能传播给猪的其他传染病的相关模型。猪霍乱沙门氏菌众多潜在的引入和传播途径值得进一步研究，以便为应对其他疾病威胁做好准备。
