基因分型HIV耐药性检测中应用的分析物概述。
Overview of the Analytes Applied in Genotypic HIV Drug Resistance Testing.
作者信息
Ji Hezhao, Sandstrom Paul
机构信息
National Microbiology Laboratory at JC Wilt Infectious Diseases Research Centre, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada.
Max Rady College of Medicine, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
出版信息
Pathogens. 2022 Jun 29;11(7):739. doi: 10.3390/pathogens11070739.
Abstract
The close monitoring of HIV drug resistance using genotypic HIV drug resistance testing (HIVDRT) has become essential for effective HIV/AIDS management at both individual and population levels. Over the years, a broad spectrum of analytes or specimens have been applied or attempted in HIVDRT; however, the suitability and performance of these analytes in HIVDRT and the clinical relevance of the results from them may vary significantly. This article provides a focused overview of the performance, strengths, and weaknesses of various analytes while used in HIVDRT, which may inform the optimal analytes selection in different application contexts.
摘要
使用基因型HIV耐药性检测（HIVDRT）对HIV耐药性进行密切监测，已成为在个体和人群层面有效管理HIV/AIDS的关键。多年来，各种各样的分析物或标本已被应用于或尝试用于HIVDRT；然而，这些分析物在HIVDRT中的适用性和性能，以及由此得出的结果的临床相关性可能有很大差异。本文重点概述了各种分析物在用于HIVDRT时的性能、优点和缺点，这可能有助于在不同应用场景中选择最佳分析物。
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