剂量分割对大鼠辐射诱发心脏病的影响。
The effects of dose-fractionation on radiation-induced heart disease in rats.
作者信息
Lauk S, Rüth S, Trott K R
出版信息
Radiother Oncol. 1987 Apr;8(4):363-7. doi: 10.1016/s0167-8140(87)80187-1.
The hearts of Wistar rats were irradiated locally with a range of total doses given in 1, 3, 5 or 10 fractions in 4 weeks. As even after the lowest single dose of 17.5 Gy all animals died within 18 months after irradiation from heart failure, no ED50 could be determined. Therefore, the mean survival time following irradiation was chosen as isoeffect for the comparison of different treatment groups. Fractionation has a marked sparing effect on the radiation-induced heart disease. For an isoeffect of a mean survival time of 42 weeks an alpha/beta of 1 Gy was found.
对Wistar大鼠的心脏进行局部照射，在4周内分1、3、5或10次给予一系列总剂量。由于即使在最低单次剂量17.5 Gy后，所有动物在照射后18个月内均因心力衰竭死亡，因此无法确定半数有效剂量（ED50）。因此，选择照射后的平均生存时间作为等效应指标，用于比较不同治疗组。分次照射对辐射诱发的心脏病有显著的保护作用。对于平均生存时间为42周的等效应，发现α/β为1 Gy。
Zotero 插件