Xing Cheng, Chen Ting, Wang Li, An Qi, Jin Yali, Yang Dezhi, Zhang Li, Du Guanhua, Lu Yang
Beijing City Key Laboratory of Polymorphic Drugs, Center of Pharmaceutical Polymorphs, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Beijing City Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Pharmaceuticals (Basel). 2022 Jun 29;15(7):807. doi: 10.3390/ph15070807.
Two novel co-crystals of naproxen (NPX) were designed and prepared at a stoichiometric ratio of 1:1, namely, naproxen-caprolactam (NPX-CPL) and naproxen-oxymatrine (NPX-OMT). The characteristics of the co-crystals were evaluated in terms of stability and solubility studies. In terms of solubility, in four kinds of solvent systems with different pH, the solubility of NPX-OMT was significantly improved compared with that of NPX, whereas the NPX-CPL showed advantages in acidic solvent systems, indicating that the co-crystals can be applied to concoct preparations depending on therapeutic purposes. Furthermore, the experimental results of the thermal analysis showed that the co-crystal NPX-OMT had better thermal stability than the co-crystal NPX-CPL. Finally, as a complement to the single crystal X-ray diffraction (SC XRD) method, the theoretical calculation based on density functional theory (DFT) was also used to reveal the intermolecular interaction of the co-crystals at the molecular level and visually display the difference between them.
设计并制备了两种化学计量比为1:1的萘普生（NPX）新型共晶体，即萘普生-己内酰胺（NPX-CPL）和萘普生-氧化苦参碱（NPX-OMT）。通过稳定性和溶解度研究对共晶体的特性进行了评估。在溶解度方面，在四种不同pH值的溶剂体系中，NPX-OMT的溶解度相比NPX有显著提高，而NPX-CPL在酸性溶剂体系中表现出优势，这表明共晶体可根据治疗目的应用于配制制剂。此外，热分析实验结果表明，共晶体NPX-OMT比共晶体NPX-CPL具有更好的热稳定性。最后，作为单晶X射线衍射（SC XRD）方法的补充，还采用基于密度泛函理论（DFT）的理论计算来揭示共晶体在分子水平上的分子间相互作用，并直观展示它们之间的差异。
