Manzoor Mobina, Raza Syed Atif, Asim Mulazim Hussain, Bukhari Nadeem Irfan, Arshad Shumaila, Zafar Uzma
Punjab University College of Pharmacy, University of the Punjab, Lahore 54000, Pakistan.
Institute of Pharmacy, Lahore College for Women University, Lahore 54000, Pakistan.
Pharmaceuticals (Basel). 2022 Jul 14;15(7):869. doi: 10.3390/ph15070869.
Plant mucilages are commonly employed as excipients in pharmaceutical manufacturing. (Lamiaceae family), a source of hydrophilic mucilage referred herein as Ocicum, was evaluated for the solubility enhancer of a model drug, aceclofenac, in solid dispersions prepared using different methods. Polymer was extracted from and solid dispersions of aceclofenac were fabricated with Ocicum or Poloxamer 407 using polymer-to-drug ratios of 1:1, 1:2 and 1:3 utilizing solvent evaporation, lyophilization and melt methods. Ocicum was evaluated for its safety via acute toxicity study including different biochemical and hematological parameters including liver and kidney profiles. Moreover, different characterization studies including melting-point, Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and differential thermal analysis (TGA) were used for evaluation of polymer and solid dispersions. Furthermore, solubility and dissolution studies were performed to confirm solubility enhancement. Ocicum was found to be safer, and different characterization studies confirmed the purity of the compounds. In addition, Ocicum exhibited up to 6.27-fold enhanced solubility as compared to pure aceclofenac; similarly, 4.51-fold increased solubility by the synthetic polymer in their respective solid dispersions was shown. Furthermore, Ocicum-based solid dispersions showed substantial improvement in dissolution of aceclofenac. Therefore, it can be concluded from the above-mentioned results that Ocicum might be used as an economical natural oral delivery carrier alternative to the synthetic polymers.
植物黏液在药物制造中通常用作辅料。对唇形科植物（本文中称为Ocicum，一种亲水性黏液的来源）作为模型药物醋氯芬酸在采用不同方法制备的固体分散体中的增溶剂进行了评估。从Ocicum中提取聚合物，并使用溶剂蒸发、冻干和熔融方法，以聚合物与药物的比例为1:1、1:2和1:3，用Ocicum或泊洛沙姆407制备醋氯芬酸的固体分散体。通过急性毒性研究评估Ocicum的安全性，包括不同的生化和血液学参数，如肝脏和肾脏指标。此外，还使用了不同的表征研究，包括熔点、傅里叶变换红外光谱（FTIR）、X射线衍射（XRD）、扫描电子显微镜（SEM）、差示扫描量热法（DSC）和差热分析（TGA）来评估聚合物和固体分散体。此外，进行了溶解度和溶出度研究以确认溶解度的提高。发现Ocicum更安全，不同的表征研究证实了化合物的纯度。此外，与纯醋氯芬酸相比，Ocicum的溶解度提高了6.27倍；同样，合成聚合物在其各自的固体分散体中的溶解度提高了4.51倍。此外，基于Ocicum的固体分散体显示醋氯芬酸的溶出度有显著改善。因此，从上述结果可以得出结论，Ocicum可能用作合成聚合物的一种经济的天然口服给药载体替代品。
