Truong Trang T T, Panizzutti Bruna, Kim Jee Hyun, Walder Ken
IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong 3220, Australia.
Mental Health Theme, The Florey Institute of Neuroscience and Mental Health, Parkville 3010, Australia.
Pharmaceutics. 2022 Jul 14;14(7):1464. doi: 10.3390/pharmaceutics14071464.
Despite advances in pharmacology and neuroscience, the path to new medications for psychiatric disorders largely remains stagnated. Drug repurposing offers a more efficient pathway compared with de novo drug discovery with lower cost and less risk. Various computational approaches have been applied to mine the vast amount of biomedical data generated over recent decades. Among these methods, network-based drug repurposing stands out as a potent tool for the comprehension of multiple domains of knowledge considering the interactions or associations of various factors. Aligned well with the poly-pharmacology paradigm shift in drug discovery, network-based approaches offer great opportunities to discover repurposing candidates for complex psychiatric disorders. In this review, we present the potential of network-based drug repurposing in psychiatry focusing on the incentives for using network-centric repurposing, major network-based repurposing strategies and data resources, applications in psychiatry and challenges of network-based drug repurposing. This review aims to provide readers with an update on network-based drug repurposing in psychiatry. We expect the repurposing approach to become a pivotal tool in the coming years to battle debilitating psychiatric disorders.
尽管药理学和神经科学取得了进展，但用于治疗精神疾病的新药研发之路在很大程度上仍然停滞不前。与从头研发新药相比，药物重新利用提供了一条成本更低、风险更小的更高效途径。各种计算方法已被应用于挖掘近几十年来产生的大量生物医学数据。在这些方法中，基于网络的药物重新利用作为一种强大的工具脱颖而出，它能够考虑各种因素的相互作用或关联，从而理解多个知识领域。基于网络的方法与药物研发中多药理学范式的转变高度契合，为发现用于治疗复杂精神疾病的重新利用候选药物提供了巨大机遇。在本综述中，我们阐述了基于网络的药物重新利用在精神病学中的潜力，重点关注以网络为中心进行重新利用的动机、主要的基于网络的重新利用策略和数据资源、在精神病学中的应用以及基于网络的药物重新利用所面临的挑战。本综述旨在为读者提供有关基于网络的药物重新利用在精神病学领域的最新情况。我们期望这种重新利用方法在未来几年成为对抗使人衰弱的精神疾病的关键工具。
