Morales-Ferra Dulce Lourdes, Zavala-Sánchez Miguel Ángel, Jiménez-Ferrer Enrique, González-Cortazar Manasés, Zamilpa Alejandro
Doctorado en Ciencias Biológicas y de la Salud, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana (UAM), México City 04960, Mexico.
Centro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social (IMSS), Argentina 1, Centro, Xochitepec CP 62790, Mexico.
Plants (Basel). 2022 Jul 7;11(14):1794. doi: 10.3390/plants11141794.
Metabolic syndrome is a constellation of abnormalities related to insulin resistance with an unfortunately high prevalence worldwide. (L.) Juss. Ex Kunth. is a well-known medicinal plant that has been studied in several biological models related to diabetes mellitus. The aim of this study was to evaluate the effects of on a hypercaloric diet-induced metabolic syndrome model. An organic fraction obtained using liquid-liquid separation from the hydroalcoholic extract of and four subfractions of this organic fraction were administered for ten weeks to C57BL6J male mice previously fed with a hypercaloric diet. The hypercaloric diet caused changes in glucose levels (from 65.3 to 221.5 mg/dL), body weight (31.3 to 42.2 g), triglycerides (91.4 to 177.7 mg/dL), systolic (89.9 to 110.3 mmHg) and diastolic (61.6 to 73.7 mg/dL) blood pressure, and insulin resistance (4.47 to 5.16). Treatment with resulted in improvements in triglycerides (83.4-125.0 mg/dL), systolic blood pressure (75.1-91.8 mmHg), and insulin resistance (4.72-4.93). However, the organic fraction and hydroalcoholic extract produced a better response in diastolic blood pressure (52.8-56.4 mmHg). Luteolin, apigenin, and chrysoeriol were the major constituents in the most active subfractions. Treatment with , particularly a luteolin-rich organic fraction, achieved an improvement in metabolic syndrome alterations.
代谢综合征是一组与胰岛素抵抗相关的异常情况，在全球范围内具有令人遗憾的高患病率。(L.) Juss. Ex Kunth. 是一种著名的药用植物，已在多种与糖尿病相关的生物学模型中进行了研究。本研究的目的是评估其对高热量饮食诱导的代谢综合征模型的影响。使用液-液分离法从其水醇提取物中获得的有机部分及其四个亚组分，对先前喂食高热量饮食的C57BL6J雄性小鼠给药十周。高热量饮食导致血糖水平（从65.3毫克/分升降至221.5毫克/分升）、体重（从31.3克增至42.2克）、甘油三酯（从91.4毫克/分升降至177.7毫克/分升）、收缩压（从89.9毫米汞柱升至110.3毫米汞柱）和舒张压（从61.6毫米汞柱升至73.7毫米汞柱）以及胰岛素抵抗（从4.47增至5.16）发生变化。用其进行治疗可改善甘油三酯（83.4 - 125.0毫克/分升）、收缩压（75.1 - 91.8毫米汞柱）和胰岛素抵抗（4.72 - 4.93）。然而，有机部分和水醇提取物对舒张压（52.8 - 56.4毫米汞柱）产生了更好的反应。木犀草素、芹菜素和 Chrysoeriol 是最活跃亚组分中的主要成分。用其进行治疗，特别是富含木犀草素的有机部分，可改善代谢综合征的改变。
