在薄荷醇作为固体共增塑剂存在的情况下，聚（环氧乙烷）-聚（环氧丙烷）-聚（环氧乙烷）三嵌段聚合物在超临界二氧化碳中的熔点降低

Melting Point Depression of Poly(ethylene oxide)-Poly(propylene oxide)-Poly(ethylene oxide) Triblock Polymers in Supercritical Carbon Dioxide in the Presence of Menthol as a Solid Co-Plasticiser.

作者信息

Trivedi Vivek, Ajiboye Adejumoke Lara, Coleman Nichola J, Bhomia Ruchir, Bascougnano Marion

机构信息

Medway School of Pharmacy, University of Kent, Central Avenue, Chatham Maritime, Kent ME4 4TB, UK.

Department of Pharmaceutical, Chemical and Environmental Science, University of Greenwich, Central Avenue, Chatham Maritime, Kent ME4 4TB, UK.

出版信息

Polymers (Basel). 2022 Jul 11;14(14):2825. doi: 10.3390/polym14142825.

The melting behaviour of the triblock polymers, Pluronic F38, F68, F77, F108, and F127, was investigated in pressurised CO and in the presence of menthol. The melting points of the polymers combined with 0, 10, 25, and 50 wt% of menthol were studied at atmospheric pressure and compared with those at 10 and 20 MPa in supercritical carbon dioxide (scCO). The highest melting point depressions of 16.8 ± 0.5 °C and 29.0 ± 0.3 °C were observed at 10 and 20 MPa, respectively. The melting point of triblock polymers in pressurised CO was found to be dependent on molecular weight, poly(propylene oxide) (PPO) content, and menthol percentage. The melting point of most of the polymers studied in this work can be reduced to room temperature, which can be pivotal to the formulation development of thermolabile substances using these polymers.