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负载辣木叶提取物多酚类化合物的淀粉基水凝胶纳米颗粒在双酚A诱导的动物模型中具有肝脏保护活性。

Starch-Based Hydrogel Nanoparticles Loaded with Polyphenolic Compounds of Moringa Oleifera Leaf Extract Have Hepatoprotective Activity in Bisphenol A-Induced Animal Models.

作者信息

Abou El-Naga Hend Mohamed Hasanin, El-Hashash Samah A, Yasen Ensaf Mokhtar, Leporatti Stefano, Hanafy Nemany A N

机构信息

Nutrition and Food Science Department, Faculty of Home Economics, Al-Azhar University, Nawag, Tanta P.O. Box 31732, Egypt.

Cnr Nanotec-Istituto di Nanotecnologia, Via Monteroni, 73100 Lecce, Italy.

出版信息

Polymers (Basel). 2022 Jul 13;14(14):2846. doi: 10.3390/polym14142846.

DOI:10.3390/polym14142846
PMID:35890622
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9324559/
Abstract

Bisphenol A (BPA) is an xenoestrogenic chemical used extensively in the fabrication of baby bottles, reusable plastic water bottles and polycarbonate plastic containers. The current study aims to investigate the hepatoprotective activity of Lam leaf extract (MOLE) and hydrogel NPs made of starch-MOLE-Bovine Serum Albumin (BSA) against Bisphenol A-induced liver toxicity in male rats. Fabrication and characterization of hydrogel NPs formed of starch-MOLE-BSA were investigated using FTIR, TEM, zeta potential, UV-visible spectroscopy and fluorescence spectrophotometer. The potential efficacy of hydrogel NPs was studied. Compared to the results of control, the level of liver function, oxidative stress markers and lipid profile status were remodulated in the groups treated with MOLE and hydrogel NPs (Encap. MOLE). Meanwhile, the administration of MOLE and Encap MOLE significantly increased antioxidant activity and decreased the level of apoptotic pathways. Heme oxygenase (HO)-1 and growth arrest -DNA damage-inducible gene 45b (Gadd45b) were also regulated in the groups treated with MOLE and Encap. MOLE compared to the group which received BPA alone. In the present study, MOLE and hydrogel NPs led to remarkable alterations in histological changes during BPA administration. Overall, MOLE has a potential antioxidant activity which can be used in the treatment of liver disorders.

摘要

双酚A（BPA）是一种具有外源性雌激素作用的化学物质，广泛应用于婴儿奶瓶、可重复使用的塑料水瓶和聚碳酸酯塑料容器的制造中。本研究旨在探讨辣木叶提取物（MOLE）以及由淀粉-MOLE-牛血清白蛋白（BSA）制成的水凝胶纳米颗粒对双酚A诱导的雄性大鼠肝脏毒性的肝脏保护活性。采用傅里叶变换红外光谱（FTIR）、透射电子显微镜（TEM）、zeta电位、紫外可见光谱和荧光分光光度计对由淀粉-MOLE-BSA形成的水凝胶纳米颗粒进行了制备和表征。研究了水凝胶纳米颗粒的潜在功效。与对照组结果相比，用MOLE和水凝胶纳米颗粒（包封MOLE）处理组的肝功能水平、氧化应激标志物和血脂状况得到了调节。同时，给予MOLE和包封MOLE显著提高了抗氧化活性，并降低了凋亡途径的水平。与仅接受双酚A处理的组相比，用MOLE和包封MOLE处理组的血红素加氧酶（HO）-1和生长停滞及DNA损伤诱导基因45b（Gadd45b）也受到了调节。在本研究中，MOLE和水凝胶纳米颗粒在双酚A给药期间导致了组织学变化的显著改变。总体而言，MOLE具有潜在的抗氧化活性，可用于治疗肝脏疾病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f96a/9324559/042c01e87b25/polymers-14-02846-g013.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f96a/9324559/9d7c5a24c337/polymers-14-02846-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f96a/9324559/bdb0ace650db/polymers-14-02846-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f96a/9324559/c37279c535c7/polymers-14-02846-g010.jpg
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