Nanomedicine group, Institute of Nanoscience and Nanotechnology, Kafrelsheikh University, 33516 Kafrelsheikh, Egypt.
Int J Biol Macromol. 2021 Jul 31;183:171-181. doi: 10.1016/j.ijbiomac.2021.04.131. Epub 2021 Apr 23.
Many reports have been published recently confirmed the limitation of cargo molecules delivered into the heart. This failure is mostly associated with lymphatic or vascular channels washing or to the immune system recognition. Delivery of anthocyanins by encapsulation may augment it retention in the heart at early time points as the capsules are too large to wash out by lymphatic or venous channels and the physical structure of the capsule may shield the anthocyanins from immunoglobulins and cellular components of the immune system. In the current study, the cardiac dysfunction was induced by using carbon tetrachloride and then animal were treated orally by using anthocyanins incorporated into hydrogel NPs twice time /week for 4 weeks. The results showed anthocyanin loaded hydrogel NPs has ability to re-maintain the glycogen content in the liver and heart tissues of fibrotic group (13 ± 1.4 and 5 ± 0.7 μmol glucose/g tissue). Additionally, MDA and hydroxyproline were significantly reduced. PAS stain showed depletion of glycogen granules from heart tissue. It is concluded that starch based hydrogel loaded by anthocyanins can improve histological cardiac functions after their injury .
最近有许多报告证实，货物分子递送到心脏的局限性。这种失败主要与淋巴或血管通道冲洗或免疫系统识别有关。通过封装将花色苷递送到心脏，可以增加花色苷在早期的保留率，因为胶囊太大，无法通过淋巴或静脉通道冲洗掉，并且胶囊的物理结构可能会使花色苷免受免疫球蛋白和免疫系统的细胞成分的影响。在本研究中，使用四氯化碳诱导心脏功能障碍，然后通过每周两次口服将花色苷包封到水凝胶 NPs 中，持续 4 周来对动物进行治疗。结果表明，花色苷负载水凝胶 NPs 能够维持纤维化组肝脏和心脏组织中的糖原含量（13±1.4 和 5±0.7μmol 葡萄糖/组织）。此外，MDA 和羟脯氨酸的含量明显降低。PAS 染色显示心脏组织中糖原颗粒的耗竭。结论：负载花色苷的淀粉基水凝胶可以改善损伤后的心脏组织的组织学功能。
