Lund Lene Dahl, Løwe Mette Margrethe, Hendricks Oliver, Schreiber Karen, Glintborg Bente, Petersen Randi, Plischke Christiane, Fick Willy, Primdahl Jette
University College UC SYD, Research Center of Applied Health Science, 6705 Esbjerg, Denmark.
Danish Hospital for Rheumatic Diseases, University Hospital of Southern Denmark, 6400 Sønderborg, Denmark.
Vaccines (Basel). 2022 Jun 21;10(7):982. doi: 10.3390/vaccines10070982.
People with inflammatory arthritis (IA) treated with immunosuppressive disease-modifying anti-rheumatic drugs (DMARDs) were initially considered to have an increased risk of severe illness from the SARS-CoV-2 virus compared to the general population. The aim of this study was to explore how people with IA experienced restrictions during the pandemic and the possible impact of vaccination on their protection against COVID-19 and their everyday lives. Nineteen people with IA were interviewed in May-August 2021; shortly thereafter they were enrolled in the Danish national COVID-19 vaccination programme. Concurrently, society gradually reopened after a national complete lockdown. The analysis was inspired by inductive qualitative content analysis. Participants expressed a lack of targeted information on the specific risk associated with IA if they contracted COVID-19. They had to define their own level of daily-life restrictions to protect themselves and their families. They were impacted by inconsistent announcements by the authorities, and some expressed concerns regarding the potential influence of DMARDs on vaccine effectiveness. A societal spirit of being "in this together" emerged through the lockdown, and some were concerned that the reduced level of restrictions in the reopened society would put them at higher risk of a COVID-19 infection and force them to continue self-isolating.
与普通人群相比，接受免疫抑制性病情缓解抗风湿药物（DMARDs）治疗的炎性关节炎（IA）患者最初被认为感染新型冠状病毒（SARS-CoV-2）后患重症的风险增加。本研究的目的是探讨IA患者在疫情期间如何经历限制措施，以及疫苗接种对他们预防新冠病毒（COVID-19）及其日常生活的可能影响。2021年5月至8月对19名IA患者进行了访谈；此后不久，他们被纳入丹麦国家COVID-19疫苗接种计划。与此同时，在全国全面封锁后，社会逐渐重新开放。分析采用归纳定性内容分析法。参与者表示，如果感染COVID-19，缺乏关于与IA相关的特定风险的针对性信息。他们必须自行确定日常生活限制的程度以保护自己和家人。他们受到当局前后不一致公告的影响，一些人对DMARDs对疫苗效力的潜在影响表示担忧。在封锁期间出现了一种“同舟共济”的社会精神，一些人担心重新开放的社会中限制措施的减少会使他们感染COVID-19的风险更高，并迫使他们继续自我隔离。
