James Stephanie, Haight Robert C, Hanna Cassandra, Furton Lindsey
School of Pharmacy, Regis University, Denver, CO 80221, USA.
Department of Pharmacotherapy, College of Pharmacy, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
Vaccines (Basel). 2022 Jul 19;10(7):1145. doi: 10.3390/vaccines10071145.
Down syndrome is caused by an extra copy of chromosome 21. In the past two decades, the life expectancy of individuals with Down syndrome has significantly increased from early 20s to early 60s, creating a population of individuals of which little is known about how well they are protected against infectious disease. The goal of this work is to better understand if adults with Down syndrome are well protected against influenza following vaccination. We obtained plasma samples from 18 adults (average age = 31yo) with Down syndrome and 17 age/gender-matched disomic individuals, all vaccinated against influenza. Antibody concentration to influenza A was measured using ELISA and antibody titers were measured using a hemagglutinin inhibition assay. Statistical analysis was performed using Stata Statistical Software. Adults with Down syndrome had a significantly increased concentration of antibodies to a mixture of influenza A viral proteins; however, they had a significantly decreased titer to the Influenza A/Hong Kong compared to disomic controls. These findings suggest that more vigorous studies of B- and T-cell function in adults with Down syndrome with respect to influenza vaccination are warranted, and that this population may benefit from a high-dose influenza vaccine.
唐氏综合征是由21号染色体多了一条所致。在过去二十年里，唐氏综合征患者的预期寿命从20岁出头显著提高到了60岁出头，这就形成了一群人，而对于他们在抵御传染病方面的情况却知之甚少。这项工作的目标是更好地了解唐氏综合征成年患者接种流感疫苗后是否能得到良好的保护。我们从18名患有唐氏综合征的成年人（平均年龄 = 31岁）和17名年龄/性别匹配的二体个体中获取了血浆样本，所有这些人都接种了流感疫苗。使用酶联免疫吸附测定法（ELISA）测量甲型流感抗体浓度，并使用血凝抑制试验测量抗体滴度。使用Stata统计软件进行统计分析。患有唐氏综合征的成年人对甲型流感病毒蛋白混合物的抗体浓度显著增加；然而，与二体对照相比，他们对甲型流感/香港株的滴度显著降低。这些发现表明，有必要对唐氏综合征成年患者在流感疫苗接种方面的B细胞和T细胞功能进行更深入的研究，并且这一人群可能会从高剂量流感疫苗中受益。
