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澳大利亚新南威尔士州丙型肝炎患者直接作用抗病毒治疗时代的及时丙型肝炎 RNA 检测和治疗。

Timely Hepatitis C RNA Testing and Treatment in the Era of Direct-Acting Antiviral Therapy among People with Hepatitis C in New South Wales, Australia.

机构信息

The Kirby Institute, UNSW Sydney, Sydney 2052, Australia.

出版信息

Viruses. 2022 Jul 8;14(7):1496. doi: 10.3390/v14071496.

Abstract

This study aimed to identify the factors associated with timely (within four weeks) HCV RNA testing and timely (within six months) DAA initiation following HCV notification in the DAA era. We conducted a cohort study of people with an HCV notification in NSW, Australia. Notifications of positive HCV serology were linked to administrative datasets. Weights were applied to account for spontaneous clearance. Logistic regression analyses were performed. Among 5582 people with an HCV notification during 2016-2017, 3867 (69%) were tested for HCV RNA, including 2770 (50%) who received timely testing. Among an estimated 3925 people with chronic HCV infection, 2372 (60%) initiated DAA therapy, including 1370 (35%) who received timely treatment. Factors associated with timely HCV RNA testing included age (≥30 years), female sex, non-Aboriginal ethnicity, country of birth being Australia, and no history of drug dependence. Factors associated with timely treatment were age (≥30 years), male sex, non-Aboriginal ethnicity, country of birth being Australia, no history of drug dependence, and HCV/HIV co-infection. In the DAA era, 50% of people with an HCV notification did not receive timely HCV RNA testing. Most people with an HCV infection received therapy; however, DAA initiation was delayed among many.

摘要

本研究旨在确定在 DAA 时代 HCV 通知后,与及时(4 周内)进行 HCV RNA 检测和及时(6 个月内)开始 DAA 治疗相关的因素。我们对澳大利亚新南威尔士州 HCV 通知人群进行了队列研究。HCV 血清学阳性的通知与行政数据集相关联。我们应用权重来解释自然清除率。进行了逻辑回归分析。在 2016-2017 年期间有 5582 人收到 HCV 通知,其中 3867 人(69%)接受了 HCV RNA 检测,包括 2770 人(50%)接受了及时检测。在估计有 3925 名慢性 HCV 感染者中,2372 人(60%)开始接受 DAA 治疗,包括 1370 人(35%)接受了及时治疗。与及时 HCV RNA 检测相关的因素包括年龄(≥30 岁)、女性、非原住民种族、澳大利亚出生和无药物依赖史。与及时治疗相关的因素包括年龄(≥30 岁)、男性、非原住民种族、澳大利亚出生、无药物依赖史和 HCV/HIV 合并感染。在 DAA 时代,有 50%的 HCV 通知人群未接受及时 HCV RNA 检测。大多数 HCV 感染者接受了治疗;然而,许多人还是延迟了 DAA 治疗的开始。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b303/9319806/599d71fba246/viruses-14-01496-g001.jpg

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