Escolà-Vergé Laura, Borràs-Bermejo Blanca, Los-Arcos Ibai, Esperalba Juliana, Ferrer Carmen, Fernández-Hidalgo Nuria
Servicio de Enfermedades Infecciosas, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
Red Española para la Investigación en Enfermedades Infecciosas (REIPI RD16/0016/0003), Instituto de Salud Carlos III, Madrid, Spain.
Med Clin (Engl Ed). 2022 Aug 12;159(3):134-136. doi: 10.1016/j.medcle.2021.07.025. Epub 2022 Jul 22.
The objective was to describe the clinical characteristics and prognosis of patients with nosocomial SARS-CoV-2 infection.
An observational and prospective study was performed in a referral hospital. We included all adult patients diagnosed with nosocomial SARS-CoV-2 infection in October 2020. Nosocomial infection was defined as a negative PCR for SARS-CoV-2 on admission and a positive PCR after 7 days of hospitalization.
We included 66 cases of nosocomial SARS-CoV-2 infection: 39 (59%) men, median age at diagnosis was 74.5 years (IQR 56.8-83.1) and median Charlson comorbidity index was 3 points (IQR 1-5). Twenty-seven (41%) developed pneumonia and 13 (20%) died during admission. Mortality at 28 days was 33% (22 patients). Mortality at 28 days in the 242 patients with community-acquired SARS-CoV-2 infection who were hospitalized during the same period was 10%.
Preventive measures and early detection of nosocomial outbreaks of COVID-19 should be prioritized to minimize the negative impact of this infection.
目的是描述医院获得性新型冠状病毒肺炎（SARS-CoV-2）感染患者的临床特征和预后。
在一家转诊医院进行了一项观察性前瞻性研究。我们纳入了2020年10月所有诊断为医院获得性SARS-CoV-2感染的成年患者。医院感染定义为入院时SARS-CoV-2核酸检测（PCR）阴性，住院7天后PCR阳性。
我们纳入了66例医院获得性SARS-CoV-2感染病例：男性39例（59%），诊断时的中位年龄为74.5岁（四分位间距56.8 - 83.1），查尔森合并症指数中位数为3分（四分位间距1 - 5）。27例（41%）发生肺炎，13例（20%）在住院期间死亡。28天死亡率为33%（22例患者）。同期住院的242例社区获得性SARS-CoV-2感染患者的28天死亡率为10%。
应优先采取预防措施并早期发现COVID-19医院感染暴发，以尽量减少这种感染的负面影响。
