调查年龄和性别对伊拉克人群因过敏原注射引起的过敏反应的影响。
Investigation on the Effect of Age and Gender on Hypersensitivity Reactions due to Allergens Injection in Iraqi Population.
机构信息
Department of General Sciences, College of Basic Education, University of Mosul, Mosul, Iraq.
出版信息
Arch Razi Inst. 2022 Feb 28;77(1):359-365. doi: 10.22092/ARI.2021.356679.1892. eCollection 2022 Feb.
Hyperactivity of the immune system due to the insertion of allergens into the living body has been known as an allergic reaction. Some substances, such as pollen grains, insects' venom, house dust mite, foods, and medicines, can induce allergic responses. Therefore, this study was designed to shed light on the role of gender and age in allergic reactions resulting from some organic and chemical allergens. A total of 200 individuals participated in this study, including 70 males and 130 females. A skin test was performed by subcutaneously injecting allergens, namely amoxicillin, cefotaxine, gentamicin, spp., and . All the chemicals were purchased from Sigma-Aldrich unless otherwise stated. The spot of injection was sterilized by ethyl alcohol (70%) and well dried; subsequently, 0.05 mL of each allergen (antigen) was injected via a 1-mL medical syringe. The results showed that 140 cases were allergic. Anti-cefotaxine occupied the highest percentage among the studied drug allergens. The highest percentage of males (37.5%) that were allergic was at the age range of 28-35 years, whereas the highest percentage of females (18.5%) that were allergic was at the age range of 17-27 years. Sensitivity to amoxicillin accounted for 12.5% of males at the age range of 28-37 years and 3.7% of females at the age range of 17-27 years. Gentamicin triggered the highest percentage of sensitivity in 12.5% and 7.4% of males and females aged 48-57 years and 17-27 years, respectively. The results showed that honey bees had the highest percentage of total sensitivity at 40%. The highest sensitivity rate stood at 37.5% in males at the age range of 28-37 years and 18.5% in females at the age range of 17-27 years. Wasps recorded a total sensitivity rate of 17.1%, with the highest percentage at 37.5% in males who were aged 17-27 years and 3.7% in females at the age ranges of 17-27 and 48-57 years. The results of the statistical analysis indicated that there were significant (≤0.05) differences for all allergens that were studied regarding gender and age.
由于过敏原进入体内导致免疫系统过度活跃，这种现象被称为过敏反应。花粉粒、昆虫毒液、屋尘螨、食物和药物等物质都可能引发过敏反应。因此，本研究旨在探讨性别和年龄在某些有机和化学过敏原引起的过敏反应中的作用。共有 200 人参与了这项研究，其中包括 70 名男性和 130 名女性。通过皮下注射抗生素（阿莫西林、头孢噻肟、庆大霉素、青霉素类、头孢菌素类）和化学物质（均购自 Sigma-Aldrich，除非另有说明）进行皮肤测试。注射部位用 70%乙醇消毒并彻底干燥；随后，通过 1mL 医用注射器向每个过敏原（抗原）注射 0.05mL。结果显示，140 例过敏。在研究的药物过敏原中，头孢噻肟的过敏比例最高。男性过敏比例最高（37.5%）的年龄段为 28-35 岁，而女性过敏比例最高（18.5%）的年龄段为 17-27 岁。阿莫西林对 28-37 岁男性的敏感性占 12.5%，对 17-27 岁女性的敏感性占 3.7%。庆大霉素在 48-57 岁和 17-27 岁的男性和女性中引发的敏感性最高，分别占 12.5%和 7.4%。结果表明，蜜蜂的总敏感性最高，为 40%。男性在 28-37 岁年龄段的敏感性最高，为 37.5%，女性在 17-27 岁年龄段的敏感性最高，为 18.5%。黄蜂的总敏感性为 17.1%，其中 17-27 岁男性的敏感性最高，为 37.5%，17-27 岁和 48-57 岁女性的敏感性最高，为 3.7%。统计分析结果表明，所有研究的过敏原在性别和年龄方面均存在显著差异（≤0.05）。
Zotero 插件