过氧化物酶体增殖物激活受体α和γ基因多态性与急性冠状动脉综合征的相关性

The Correlation Between Peroxisome Proliferator-Activated Receptor Alpha and Gamma Polymorphisms and Acute Coronary Syndrome.

作者信息

Kemanci Aykut, Goren Tarik, Uluturk Mehmet, Yilmaz Atakan, Sabirli Ramazan, Ozen Mert, Seyit Murat, Oskay Alten, Koseler Aylin, Turkcuer Ibrahim

机构信息

Emergency Medicine, Tavsanli Doc. Dr. Mustafa Kalemli State Hospital, Kutahya, TUR.

Emergency Department, Medical Faculty, Pamukkale University, Deni̇zli̇, TUR.

出版信息

Cureus. 2022 Jun 21;14(6):e26147. doi: 10.7759/cureus.26147. eCollection 2022 Jun.

DOI:10.7759/cureus.26147

PMID:35891836

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9301886/

Abstract

OBJECTIVE

This study aims to evaluate the relationship between peroxisome proliferator-activated receptor (PPAR) alpha and gamma gene polymorphisms and acute coronary syndrome (ACS) clinically.

SUBJECT AND METHODS

Peripheral blood samples were collected from a total of 200 people, including 100 acute coronary syndrome patients and 100 controls aged 19 to 93 years, admitted to the Pamukkale University Emergency Medicine Department. The healthy volunteers had no known chronic or acute diseases, no history of drug use, and no recent history of coronary artery disease (CAD). PPAR alpha L162V and PPAR gamma C161T gene polymorphic regions were detected using DNA sequencing analyses. In addition, data collected from the hemogram and biochemical parameters and comorbidities of the patients were statistically analyzed.

RESULTS

PPAR gamma C161T polymorphisms were compared between groups. The CT heterozygous rate in the patient group (74%) was higher than in the control group (7%). The T allele was more common in the patient group (0.37) compared to the control group (0.03). When PPAR alpha L162V polymorphism was compared, VV homozygous individuals were %19 in the patient group and none in the control group. The V allele was found to be statistically higher in patients with ACS (p<0.01).

CONCLUSION

The findings revealed that elevated PPAR alpha L162V and PPAR gamma C161T gene polymorphisms were associated with a progressive risk of ACS.

摘要

目的

本研究旨在临床上评估过氧化物酶体增殖物激活受体（PPAR）α和γ基因多态性与急性冠状动脉综合征（ACS）之间的关系。

对象与方法

从总计200人中采集外周血样本，其中包括100例急性冠状动脉综合征患者和100名年龄在19至93岁之间的对照者，他们均入住了棉花堡大学急诊医学科。健康志愿者无已知的慢性或急性疾病，无用药史，近期也无冠状动脉疾病（CAD）史。使用DNA测序分析检测PPARα L162V和PPARγ C161T基因多态性区域。此外，对从患者的血常规、生化参数和合并症收集的数据进行了统计分析。

结果

比较了各组之间的PPARγ C161T多态性。患者组的CT杂合率（74%）高于对照组（7%）。与对照组（0.03）相比，患者组中T等位基因更为常见（0.37）。比较PPARα L162V多态性时，患者组中VV纯合个体占19%，而对照组中没有。发现ACS患者中V等位基因在统计学上更高（p<0.01）。