Goddard Jerome, Speights Cori J, Borganelli Mark
Department of Biochemistry, Molecular Biology, Entomology, and Plant Pathology, Mississippi State University, Starkville, USA.
Heart and Vascular Department, The Hattiesburg Clinic, Hattiesburg, USA.
Cureus. 2022 Jun 21;14(6):e26168. doi: 10.7759/cureus.26168. eCollection 2022 Jun.
A variety of potential triggers of atrial fibrillation (AF) have been reported, including alcohol consumption, caffeine, exercise, and stress. Vagal AF triggers include gastrointestinal factors such as the amount of food consumed, types of foods, and gas and bloating. In this case report, detailed data of seven dietary and behavioral factors (many vagal) believed to be possible atrial tachycardia (AT) or AF triggers in a single patient with paroxysmal AT/AF were recorded. Episodes of AT and AF were recorded in the patient using a Medtronic loop recorder and analyzed by a cardiac electrophysiologist. To evaluate these potential triggers of AT/AF events, a general linear model with binomial family error distribution was used to fit the data. Then, a stepAIC function from the MASS package in R was used to perform a stepwise model selection using AIC (Akaike information criterion). The analysis only identified the amount of salt intake and the use of polyethylene glycol 3350 as predictors of AT/AF, and high salt intake was the only factor significantly associated with the onset of AT/AF ( 0.05). Thus, salt intake may trigger AT/AF in ways other than via hypertension.
据报道,心房颤动(AF)有多种潜在触发因素,包括饮酒、咖啡因、运动和压力。迷走神经介导的房颤触发因素包括胃肠道因素,如食物摄入量、食物类型以及气体和腹胀。在本病例报告中,记录了一名阵发性房性心动过速(AT)/房颤患者中七种被认为可能是房性心动过速(AT)或房颤触发因素的饮食和行为因素(许多与迷走神经有关)的详细数据。使用美敦力环形记录仪记录该患者的AT和房颤发作情况,并由心脏电生理学家进行分析。为了评估这些AT/AF事件的潜在触发因素,使用了具有二项式族误差分布的广义线性模型对数据进行拟合。然后,使用R语言中MASS包的stepAIC函数,以AIC(赤池信息准则)进行逐步模型选择。分析仅确定盐摄入量和聚乙二醇3350的使用为AT/AF的预测因素,高盐摄入是与AT/AF发作显著相关的唯一因素(P<0.05)。因此,盐摄入可能通过高血压以外的方式触发AT/AF。