Laboratory of Electrochemistry-Corrosion, Metallurgy and Mineral Chemistry, Department of Chemistry, Faculty of Chemistry, Houari Boumediene University of Sciences and Technology (USTHB), Algiers, Algeria.
Laboratory of Vegetal Ecology and Environment, Department of Ecology and Environment, Faculty of Biological Sciences, Houari Boumediene University of Sciences and Technology (USTHB), Algiers, Algeria.
Drug Chem Toxicol. 2023 Nov;46(5):864-878. doi: 10.1080/01480545.2022.2104868. Epub 2022 Jul 26.
In order to know if the heavy metals stress condition is boon or bane for the plants growth, species was planted in pots under different levels of heavy metals stress condition and the phytochemical composition, cytotoxicity, antioxidant and antimicrobial responses of their leaf ethanolic extracts toward this stress condition were investigated compared to the control samples. Our findings showed significant differences in heavy metals bioaccumulation, photosynthetic pigments and total phenolic/flavonoids contents among . leafs ethanolic extracts, grown under different levels of heavy metals stress condition. The leafs extracts, grown under Zn and Cu stress condition, showed the highest antioxidant and antimicrobial activities than those grown under Cd and Pb stress condition. Comparatively, the leafs extracts, grown under Zn stress condition, showed higher antioxidant activity, and those, grown under Cu stress condition, showed higher antimicrobial activity. The highest cytotoxicity was showed by leaf extracts, grown under Cd and Pb stress condition, which lead to conclude that these extracts could be served as a novel scaffold in search for new drugs against cancer. In conclusion, the highlighted variability reflects the high impact of heavy metals stress condition on phytochemical composition and consequently on the biological activities of medicinal plants. Such impact led to conclude that we should select medicinal plants extracts to be investigated carefully depending on this stress condition, in order to isolate the bioactive components or to have the best quality of extracts in terms of biological activities.
为了了解重金属胁迫条件对植物生长是好是坏，将物种种植在不同重金属胁迫条件下的花盆中，比较其叶片乙醇提取物对这种胁迫条件的植物化学组成、细胞毒性、抗氧化和抗菌反应与对照样品。我们的研究结果表明，在不同重金属胁迫条件下生长的叶片乙醇提取物中，重金属生物积累、光合色素和总酚/类黄酮含量存在显著差异。在 Zn 和 Cu 胁迫条件下生长的叶片提取物表现出比在 Cd 和 Pb 胁迫条件下生长的叶片提取物更高的抗氧化和抗菌活性。相比之下，在 Zn 胁迫条件下生长的叶片提取物表现出更高的抗氧化活性，而在 Cu 胁迫条件下生长的叶片提取物表现出更高的抗菌活性。在 Cd 和 Pb 胁迫条件下生长的叶片提取物表现出最高的细胞毒性，这表明这些提取物可以作为寻找抗癌新药的新型支架。总之，突出的可变性反映了重金属胁迫条件对药用植物植物化学组成的重大影响，进而对其生物活性的影响。这种影响使得我们应该根据这种胁迫条件仔细选择要研究的药用植物提取物，以便分离出生物活性成分或获得具有最佳生物活性的提取物质量。
