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Analysis of cell-specific peripheral blood biomarkers in severe allergic asthma identifies innate immune dysfunction.

作者信息

Nicholas Ben, Guo Jane, Lee Hyun-Hee, Bailey Alistair, de Waal Malefyt Rene, Cicmil Milenko, Djukanovic Ratko

机构信息

Division of Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, Southampton General Hospital, Hampshire, UK.

Oncology & Immunology Discovery, Merck Research Laboratories, Boston, Massachusetts, USA.

出版信息

Clin Exp Allergy. 2022 Nov;52(11):1334-1337. doi: 10.1111/cea.14197. Epub 2022 Aug 2.

DOI:10.1111/cea.14197
PMID:35892202
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9804525/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f069/9804525/aa640935136e/CEA-52-1334-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f069/9804525/aa640935136e/CEA-52-1334-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f069/9804525/aa640935136e/CEA-52-1334-g001.jpg

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The mannose 6-phosphate/insulin-like growth factor 2 receptor mediates plasminogen-induced efferocytosis.甘露糖 6-磷酸/胰岛素样生长因子 2 受体介导纤溶酶原诱导的吞噬作用。
J Leukoc Biol. 2019 Mar;105(3):519-530. doi: 10.1002/JLB.1AB0417-160RR. Epub 2019 Jan 18.
3
Sputum proteomics and airway cell transcripts of current and ex-smokers with severe asthma in U-BIOPRED: an exploratory analysis.
嗅觉介质蛋白4作为哮喘的循环生物标志物
Ann Transl Med. 2022 Oct;10(20):1085. doi: 10.21037/atm-22-3983.
当前和曾吸烟的严重哮喘患者的痰液蛋白质组学和气道细胞转录本的 U-BIOPRED：探索性分析。
Eur Respir J. 2018 May 3;51(5). doi: 10.1183/13993003.02173-2017. Print 2018 May.
4
A Severe Asthma Disease Signature from Gene Expression Profiling of Peripheral Blood from U-BIOPRED Cohorts.基于 U-BIOPRED 队列的外周血基因表达谱分析的严重哮喘疾病特征。
Am J Respir Crit Care Med. 2017 May 15;195(10):1311-1320. doi: 10.1164/rccm.201604-0866OC.
5
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Nat Rev Dis Primers. 2015 Sep 10;1(1):15025. doi: 10.1038/nrdp.2015.25.
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