生存试验中不等分配的使用。

Use of unequal allocation in survival trials.

作者信息

Sposto R, Krailo M D

出版信息

Stat Med. 1987 Mar;6(2):119-25. doi: 10.1002/sim.4780060204.

Abstract

In some two-treatment clinical survival trials, a large imbalance in the allocation of patients to treatments will result in approximately the same power for the logrank test as equal allocation. This fact can be used in some trials to reduce significantly the number of patients allocated to a potentially inferior treatment.

摘要

在一些双治疗组的临床生存试验中，患者在治疗分配上的巨大不平衡会导致对数秩检验的效能与均等分配时大致相同。这一事实可用于某些试验，以显著减少分配到可能较差治疗组的患者数量。