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抗病毒富勒烯研究进展

Progress in Antiviral Fullerene Research.

作者信息

Xu Piao-Yang, Li Xiao-Qing, Chen Wei-Guang, Deng Lin-Long, Tan Yuan-Zhi, Zhang Qianyan, Xie Su-Yuan, Zheng Lan-Sun

机构信息

College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.

Funano New Material Technology Company Ltd., Xiamen 361110, China.

出版信息

Nanomaterials (Basel). 2022 Jul 24;12(15):2547. doi: 10.3390/nano12152547.

DOI:10.3390/nano12152547
PMID:35893515
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9330071/
Abstract

Unlike traditional small molecule drugs, fullerene is an all-carbon nanomolecule with a spherical cage structure. Fullerene exhibits high levels of antiviral activity, inhibiting virus replication in vitro and in vivo. In this review, we systematically summarize the latest research regarding the different types of fullerenes investigated in antiviral studies. We discuss the unique structural advantage of fullerenes, present diverse modification strategies based on the addition of various functional groups, assess the effect of structural differences on antiviral activity, and describe the possible antiviral mechanism. Finally, we discuss the prospective development of fullerenes as antiviral drugs.

摘要

与传统小分子药物不同，富勒烯是一种具有球形笼状结构的全碳纳米分子。富勒烯表现出高水平的抗病毒活性，可在体外和体内抑制病毒复制。在本综述中，我们系统地总结了抗病毒研究中所研究的不同类型富勒烯的最新研究。我们讨论了富勒烯独特的结构优势，基于添加各种官能团提出了多样的修饰策略，评估了结构差异对抗病毒活性的影响，并描述了可能的抗病毒机制。最后，我们讨论了富勒烯作为抗病毒药物的前瞻性发展。

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