Kubista E, Müller G, Spona J
Rev Fr Gynecol Obstet. 1987 Apr;82(4):221-7.
The therapeutic effect of a long-term Gestagen therapy (lynestrenol) and a phytotherapy (Mastodynon) in comparison to a placebo group is reported in 160 cases of severe mastopathy with cyclic mastalgia. In 82.1 percent of the patients in the gestagen-group and in 74.5 percent of the patients in the Mastodynon-group a good relief of the premenstrual symptoms was achieved. In the placebo group only 36.8 percent of the patients reported a relief of symptoms. The difference is significant. The evaluation and analysis of serum HPRL and serum-progesterone showed a significant rise of the HPRL-level and a significant decrease of the progesterone-level. Because of this severe influence on the endocrine balance the recommendation for an alternative phytotherapy prior to a long term gestagen therapy is justified.
报告了长期使用孕激素疗法（炔诺酮）和植物疗法（Mastodynon）与安慰剂组相比，对160例伴有周期性乳腺疼痛的严重乳腺病患者的治疗效果。在孕激素组中82.1%的患者以及Mastodynon组中74.5%的患者经前症状得到了很好的缓解。在安慰剂组中只有36.8%的患者报告症状有所缓解。差异具有显著性。血清泌乳素（HPRL）和血清孕酮的评估与分析显示，HPRL水平显著升高，孕酮水平显著降低。鉴于对内分泌平衡的这种严重影响，在长期孕激素治疗之前推荐采用替代性植物疗法是合理的。
