Lutz J, Stark M
Rev Fr Transfus Immunohematol. 1986 Dec;29(6):443-53. doi: 10.1016/s0338-4535(86)80076-9.
After the infusion of perfluorochemicals (PFC) given as artificial blood gas carriers a temporary storage of the inert substances in tissues of the organism occurs. The time course of this effect was investigated in longitudinal studies in the rat and compared with changes of different organ functions, expressed as changes in the levels of serum enzymes, in the elimination of indocyanine green and in the duration of pentobarbital sleeping time which are dependent on the excretory and detoxifying functions of the liver. The intensity of the elimination of colloidal carbon was used as a measure of the activity of the reticulo endothelial system. Observation of the time course of these functional tests in comparison with the storage of PFC and changes in organ weight of liver and spleen showed that diminutions in function had a distinctly shorter duration than PFC storage, whereas the longest lasting effects were seen in organ weight increase is regarded as a compensatory effect that is associated without functional loss at the maximum of its appearance.
在输注作为人工血气载体的全氟化合物（PFC）后，生物体内组织会暂时储存这些惰性物质。在对大鼠的纵向研究中调查了这种效应的时间进程，并将其与不同器官功能的变化进行比较，这些变化通过血清酶水平的变化、吲哚菁绿清除率的变化以及戊巴比妥睡眠时间的长短来表示，而这些都依赖于肝脏的排泄和解毒功能。胶体碳清除强度被用作网状内皮系统活性的指标。将这些功能测试的时间进程与PFC的储存以及肝脏和脾脏器官重量的变化进行比较后发现，功能减退的持续时间明显短于PFC的储存时间，而器官重量增加的持续时间最长，这被视为一种代偿效应，在其出现的高峰期与功能丧失无关。
