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青春期前感染活速殖子的怀孕小母牛的再激活和胎儿感染

Reactivation and Foetal Infection in Pregnant Heifers Infected with Live Tachyzoites at Prepubertal Age.

作者信息

Hecker Yanina P, Burucúa Mercedes M, Fiorani Franco, Maldonado Rivera Jaime E, Cirone Karina M, Dorsch Matías A, Cheuquepán Felipe A, Campero Lucía M, Cantón Germán J, Marín Maia S, Ortega-Mora Luis M, Moore Dadín P

机构信息

Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible (IPADS), Instituto Nacional de Tecnología Agropecuaria (INTA)-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Balcarce 7620, Argentina.

Facultad de Ciencias Agrarias, Universidad Nacional de Mar del Plata, Balcarce 7620, Argentina.

出版信息

Vaccines (Basel). 2022 Jul 25;10(8):1175. doi: 10.3390/vaccines10081175.

DOI:10.3390/vaccines10081175
PMID:35893824
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9330614/
Abstract

is recognised for causing cattle abortion, provoking severe economic losses in the livestock industry worldwide. The aim of the present study was to evaluate the reactivation and foetal infection in pregnant heifers inoculated with live tachyzoites before puberty. A total of 15 30-month-old pregnant heifers were allocated into four groups: animals inoculated with live tachyzoites of NC-Argentina LP1 isolate before puberty and challenged with live tachyzoites of NC-1 strain at 210 days of gestation (DG) (Group A); animals mock inoculated before puberty and challenged with NC-1 strain at 210 DG (Group B), animals inoculated before puberty but not subsequently challenged (Group C); and noninfected and nonchallenged animals (Group D). The results of this study showed that 100% of animals infected before puberty (Groups A and C) suffered reactivation of the infection at the seventh month of gestation. In addition, in three and two calves from Groups A and C, respectively, congenital infection was confirmed. Interestingly, we provide evidence that the use of live tachyzoites in young animals as a strategy to induce protection is neither safe nor effective.

摘要

它因导致牛流产而闻名，在全球畜牧业中引发了严重的经济损失。本研究的目的是评估青春期前接种活速殖子的怀孕小母牛的感染再激活情况和胎儿感染情况。总共15头30月龄的怀孕小母牛被分为四组：青春期前接种NC-阿根廷LP1分离株的活速殖子并在妊娠210天（DG）时用NC-1株的活速殖子进行攻毒的动物（A组）；青春期前进行 mock 接种并在210 DG时用NC-1株进行攻毒的动物（B组），青春期前接种但随后未进行攻毒的动物（C组）；以及未感染且未攻毒的动物（D组）。本研究结果表明，青春期前感染的动物（A组和C组）中有100%在妊娠第七个月时感染再激活。此外，分别在A组和C组的三头和两头小牛中证实了先天性感染。有趣的是，我们提供的证据表明，在幼龄动物中使用活速殖子作为诱导保护的策略既不安全也无效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/175e/9330614/4b1e0c9951bf/vaccines-10-01175-g003a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/175e/9330614/e1b99e65f846/vaccines-10-01175-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/175e/9330614/da104b77e9c7/vaccines-10-01175-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/175e/9330614/4b1e0c9951bf/vaccines-10-01175-g003a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/175e/9330614/e1b99e65f846/vaccines-10-01175-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/175e/9330614/da104b77e9c7/vaccines-10-01175-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/175e/9330614/4b1e0c9951bf/vaccines-10-01175-g003a.jpg

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本文引用的文献

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The Effect of Vaccination with Live-Frozen Tachyzoites on Abortion Rates of Naturally Infected Pregnant Cows.用活冻速殖子疫苗接种对自然感染的怀孕母牛流产率的影响。
Vaccines (Basel). 2021 Apr 19;9(4):401. doi: 10.3390/vaccines9040401.
2
Innate and humoral immune parameters at delivery in colostrum and calves from heifers experimentally infected with Neospora caninum.初乳和经实验感染犬新孢子虫的小母牛所产犊牛在分娩时的固有免疫和体液免疫参数。
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The evaluation of attenuated Neospora caninum by long-term passages on murine macrophage cell line in prevention of vertical transmission in mice.
用鼠巨噬细胞系进行长期传代来评估减弱的刚地弓形虫，以预防小鼠的垂直传播。
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Immune response to Neospora caninum live tachyzoites in prepubertal female calves.未成熟雌性小牛对刚地弓形虫活速殖子的免疫反应。
Parasitol Res. 2019 Oct;118(10):2945-2955. doi: 10.1007/s00436-019-06447-y. Epub 2019 Sep 4.
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Immune response in bovine neosporosis: Protection or contribution to the pathogenesis of abortion.牛新孢子虫病中的免疫反应：对流产发病机制的保护作用还是促成作用。
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Vaccines for bovine neosporosis: current status and key aspects for development.牛新孢子虫病疫苗：现状与研发关键要点
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