Department of Cardiac Rehabilitation, Kitasato University Kitasato Institute Hospital, Minato-ku 108-8642, Japan.
Department of Cardiovascular Medicine, Kitasato University School of Medicine, Sagamihara 252-0375, Japan.
Nutrients. 2022 Jul 24;14(15):3032. doi: 10.3390/nu14153032.
Advanced glycated end products (AGEs) accumulate systemically and cause diabetes complications. However, whether noninvasive measurable AGEs are associated with diabetes status and physical functions remains unclear. One hundred and ten patients with cardiovascular disease (CVD) who underwent outpatient cardiac rehabilitation were included. AGEs scores, using AGEs sensors, were evaluated concomitantly with a physical evaluation, including testing the isometric knee extension strength (IKES) and 6 min walking distance (6MWD). Thirty-three (30%) patients had a history of diabetes mellitus (DM). The AGEs score was not different in the presence of DM history (0.52 ± 0.09 vs. 0.51 ± 0.09, p = 0.768) and was not correlated with blood glucose (r = 0.001, p = 0.995). The AGEs score was positively correlated with hemoglobin A1c (HbA1c, r = 0.288, p = 0.004) and negatively correlated with physical functions (IKES, r = −0.243, p = 0.011; 6MWD, r = −0.298, p = 0.002). The multivariate analysis demonstrated that 6MWD was independently associated with a high AGEs score (>0.52). The AGEs score was associated with HbA1c, IKES, and 6MWD in patients with CVD. The AGEs score might be a useful indicator for evaluating not only glycemic control but also physical functions.
糖基化终产物（AGEs）在体内蓄积并导致糖尿病并发症。然而，非侵入性可测量的 AGEs 是否与糖尿病状态和身体功能有关尚不清楚。我们纳入了 110 名接受门诊心脏康复的心血管疾病（CVD）患者。同时使用 AGEs 传感器评估 AGEs 评分，并进行身体评估，包括等长膝关节伸展力量（IKES）和 6 分钟步行距离（6MWD）测试。33 名（30%）患者有糖尿病病史（DM）。有 DM 病史的患者的 AGEs 评分没有差异（0.52 ± 0.09 与 0.51 ± 0.09，p = 0.768），且与血糖无相关性（r = 0.001，p = 0.995）。AGEs 评分与糖化血红蛋白（HbA1c，r = 0.288，p = 0.004）呈正相关，与身体功能呈负相关（IKES，r = -0.243，p = 0.011；6MWD，r = -0.298，p = 0.002）。多变量分析表明，6MWD 与高 AGEs 评分（>0.52）独立相关。AGEs 评分与 CVD 患者的 HbA1c、IKES 和 6MWD 相关。AGEs 评分可能是评估血糖控制和身体功能的有用指标。
