血清戊糖苷与2型糖尿病患者的心脏功能障碍和动脉粥样硬化有关。
Serum Pentosidine is Associated with Cardiac Dysfunction and Atherosclerosis in T2DM.
作者信息
Cao Yuyan, Ye Xinhua, Yuan Xiaoqing, Liu Juan, Zhang Qing
机构信息
Department of Endocrinology, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, People's Republic of China.
Changzhou Medical Center, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, People's Republic of China.
出版信息
Diabetes Metab Syndr Obes. 2023 Jan 26;16:237-244. doi: 10.2147/DMSO.S398119. eCollection 2023.
AIM
The purpose of this paper is to investigate the relationship between serum pentosidine levels and cardiac function and vascular disease in diabetic patients, and to provide a new reference indicator for the early detection of diabetic cardiovascular complications.
MATERIALS AND METHODS
This was a cross-sectional study. One hundred and twenty-two patients with type 2 diabetes were grouped by LVEF quartiles to compare the differences between their clinical data and serum pentosidine levels. Also, the correlation between serum pentosidine and clinical indicators was assessed. The effect of serum pentosidine on cardiac function and vascular stiffness was analyzed by multiple stepwise regression.
RESULTS
Serum pentosidine levels were higher in patients with LVEF ≤57%. Serum pentosidine levels were positively correlated with waist-to-hip ratio, hemoglobin, AIP, baPWV, LVESD, and ARD, and negatively correlated with LVEF. Low serum pentosidine was associated with increased LVESD; high pentosidine was significantly associated with increased ARD, high AIP and high baPWV.
CONCLUSION
The results suggest that serum pentosidine, a member of AGEs, may reflect cardiac remodeling and dysfunction as well as atherosclerosis.
目的
本文旨在探讨糖尿病患者血清戊糖苷水平与心脏功能及血管疾病之间的关系，为糖尿病心血管并发症的早期检测提供新的参考指标。
材料与方法
这是一项横断面研究。将122例2型糖尿病患者按左心室射血分数（LVEF）四分位数分组，比较其临床资料和血清戊糖苷水平的差异。此外，评估血清戊糖苷与临床指标之间的相关性。通过多元逐步回归分析血清戊糖苷对心脏功能和血管硬度的影响。
结果
LVEF≤57%的患者血清戊糖苷水平较高。血清戊糖苷水平与腰臀比、血红蛋白、动脉粥样硬化指数（AIP）、臂踝脉搏波速度（baPWV）、左心室舒张末期内径（LVESD）和动脉硬化指数（ARD）呈正相关，与LVEF呈负相关。低血清戊糖苷与LVESD增加有关；高戊糖苷与ARD增加、高AIP和高baPWV显著相关。
结论
结果表明，血清戊糖苷作为晚期糖基化终产物（AGEs）的一员，可能反映心脏重塑和功能障碍以及动脉粥样硬化。
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