School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, Guangdong 529020, P. R. China.
State Key Laboratory of Applied Organic Chemistry & College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P. R. China.
Org Lett. 2022 Aug 5;24(30):5624-5628. doi: 10.1021/acs.orglett.2c02399. Epub 2022 Jul 27.
A palladium catalyzed dicarbonylation of α-iodo-substituted ACPs for the synthesis of carbamoyl substituted indenones has been developed. Two carbonyl groups were incorporated into the product with the cleavage of the proximal C-C bond of the ACPs. A broad range of carbamoyl substituted indenones were efficiently prepared in good to excellent yields.
发展了一种钯催化的α-碘代 ACPs 的双羰基化反应，用于合成氨基甲酰取代的茚酮。通过 ACPs 的近端 C-C 键的断裂，将两个羰基基团引入到产物中。合成了一系列广泛的氨基甲酰取代的茚酮，产率良好至优秀。
