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钯和布朗斯特酸催化的亚烷基环丙烷与亚胺的对映、位点和 / -选择性加成反应。

Palladium- and Brønsted acid-catalyzed enantio-, site- and /-selective addition of alkylidenecyclopropanes with imines.

作者信息

Liu Xin-Lian, Lin Han-Ze, Tan Lu-Qi, Peng Jin-Bao

机构信息

School of Biotechnology and Health Sciences, Wuyi University Jiangmen Guangdong 529020 People's Republic of China

出版信息

Chem Sci. 2023 Feb 4;14(9):2348-2352. doi: 10.1039/d2sc05674g. eCollection 2023 Mar 1.

DOI:10.1039/d2sc05674g
PMID:36873841
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9977444/
Abstract

Transition-metal catalyzed functionalization of ACPs has been widely investigated in cycloaddition and 1,3-difunctionalization reactions. However, the transition metal catalyzed nucleophilic reactions of ACPs have rarely been reported. In this article, an enantio-, site- and /-selective addition of ACPs with imines for the synthesis of dienyl substituted amines has been developed palladium- and Brønsted acid co-catalysis. A range of synthetically valuable dienyl substituted amines were effectively prepared with good to excellent yields and excellent enantio- and /-selectivities.

摘要

过渡金属催化的联烯丙基化合物（ACPs）官能化反应已在环加成反应和1,3-双官能化反应中得到广泛研究。然而，过渡金属催化的ACPs亲核反应却鲜有报道。在本文中，已开发出一种通过钯和布朗斯特酸共催化实现ACPs与亚胺的对映、位点和区域选择性加成反应，用于合成二烯基取代胺。一系列具有合成价值的二烯基取代胺得以有效制备，产率良好至优异，对映选择性和区域选择性均极佳。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93d7/9977444/ab11e44fea41/d2sc05674g-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93d7/9977444/c6446e541b4e/d2sc05674g-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93d7/9977444/3fb6324d44a7/d2sc05674g-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93d7/9977444/9246b65a3b53/d2sc05674g-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93d7/9977444/ab11e44fea41/d2sc05674g-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93d7/9977444/c6446e541b4e/d2sc05674g-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93d7/9977444/3fb6324d44a7/d2sc05674g-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93d7/9977444/9246b65a3b53/d2sc05674g-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93d7/9977444/ab11e44fea41/d2sc05674g-s4.jpg

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