Zheng Nannan, Wang Qinghui, Zhang Shijin, Mao Chenchen, He Liangcan, Liu Shaoqin
School of Medicine and Health, Key Laboratory of Microsystems and Microstructures Manufacturing (Ministry of Education), Harbin Institute of Technology, Harbin, 150001, China.
Department of Electrical, Computer and Energy Engineering, University of Colorado Boulder, Boulder, Colorado, 80303, USA.
J Mater Chem B. 2022 Sep 28;10(37):7450-7459. doi: 10.1039/d2tb00935h.
Mitochondria play a critical role in cell growth and metabolism. And mitochondrial dysfunction is closely related to various diseases, such as cancers, and neurodegenerative and cardiovascular diseases. Therefore, it is of vital importance to monitor mitochondrial dynamics and function. One of the most widely used methods is to use nanotechnology-mediated mitochondria targeting and imaging. It has gained increasing attention in the past few years because of the flexibility, versatility and effectiveness of nanotechnology. In the past few years, researchers have implemented various types of design and construction of the mitochondrial structure dependent nanoprobes following assorted nanotechnology pathways. This review presents an overview on the recent development of mitochondrial structure dependent target imaging probes and classifies it into two main sections: mitochondrial membrane targeting and mitochondrial microenvironment targeting. Also, the significant impact of previous research as well as the application and perspectives will be demonstrated.
线粒体在细胞生长和代谢中起着关键作用。线粒体功能障碍与各种疾病密切相关，如癌症、神经退行性疾病和心血管疾病。因此，监测线粒体动态和功能至关重要。最广泛使用的方法之一是利用纳米技术介导的线粒体靶向和成像。由于纳米技术的灵活性、多功能性和有效性，在过去几年中它受到了越来越多的关注。在过去几年里，研究人员沿着各种纳米技术途径，实施了多种类型的依赖线粒体结构的纳米探针的设计与构建。本综述概述了依赖线粒体结构的靶向成像探针的最新进展，并将其分为两个主要部分：线粒体膜靶向和线粒体微环境靶向。此外，还将展示先前研究的重大影响以及应用和前景。
