镍催化环氧化物与芳基三氟甲磺酸酯的交叉偶联反应：快速和区域选择性构建芳基酮。
Nickel-catalyzed cross-coupling of epoxides with aryltriflates: rapid and regioselective construction of aryl ketones.
机构信息
Frontiers Science Center for Flexible Electronics (FSCFE), Shaanxi Institute of Flexible Electronics (SIFE) & Shaanxi Institute of Biomedical Materials and Engineering (SIBME), Northwestern Polytechnical University (NPU), 127 West Youyi Road, Xi'an, 710072, P. R. China.
Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, Chongqing, 401331, P. R. China.
出版信息
Chem Commun (Camb). 2022 Aug 16;58(66):9214-9217. doi: 10.1039/d2cc02891c.
Aryl ketones are one of the most important classes of organic compounds, and widely present in various pharmacological compounds, biologically active molecules and functional materials. Presented herein is a facile synthetic method for the construction of ketones Ni-catalyzed cross coupling of epoxides with aryltriflates. A range of easily accessible epoxides can be highly regioselectively converted to the corresponding aryl ketones with good yields in a redox neutral fashion.
芳基酮是最重要的有机化合物之一，广泛存在于各种药理化合物、生物活性分子和功能材料中。本文提出了一种通过 Ni 催化环氧化物与芳基三氟甲磺酸酯的交叉偶联构建酮的简便合成方法。一系列易于获得的环氧化物可以以高区域选择性和良好的收率在氧化还原中性条件下转化为相应的芳基酮。
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