Spinello Brian J, Strong Zachary H, Ortiz Eliezer, Evarts Maddie M, Krische Michael J
University of Texas at Austin, Department of Chemistry, Welch Hall (A5300), 105 E 24 St., Austin, TX 78712, USA.
ACS Catal. 2023 Aug 18;13(16):10976-10987. doi: 10.1021/acscatal.3c02209. Epub 2023 Aug 4.
Intermolecular metal-catalyzed C‒C couplings of unactivated primary alcohols or aldehydes to form ketones are catalogued. Reactions are classified on the basis of pronucleophile. Protocols involving premetalated reagents or reactants that incorporate directing groups are not covered. These methods represent an emerging alternative to classical multi-step protocols for ketone construction that exploit premetalated reagents, and/or steps devoted to redox manipulations and carboxylic acid derivatization.
未活化的伯醇或醛分子间金属催化的C-C偶联反应生成酮的反应已被编目。反应根据亲核试剂进行分类。涉及预金属化试剂或含有导向基团的反应物的方案不包括在内。这些方法是用于构建酮的经典多步方案的新兴替代方法，经典方案利用预金属化试剂和/或涉及氧化还原操作和羧酸衍生化的步骤。
