Gowsia Ishrat, Mir Feroz A, Banday Javid A
Natural Products Research Lab, Department of Chemistry, National Institute of Technology Srinagar, Srinagar, J & K, 190006, India.
Department of Physics, Baba Ghulam Shah Badshah University, Rajouri, J & K, 185234, India.
Prog Biomater. 2022 Sep;11(3):281-295. doi: 10.1007/s40204-022-00195-6. Epub 2022 Jul 27.
Piperic acid, a natural product-based derivative, has been used with polyvinyl alcohol for the first time to form polymer composite films for its suitable modification in physicochemical and antimicrobial properties. Initially, piperic acid was synthesized from piperine, a natural alkaloid extracted from black pepper (Piper nigrum). The solvent casting method was used for the synthesis of PVA-piperic acid composite films. The films were characterized by various spectral and microscopic techniques like UV-visible spectroscopy, FT-IR, SEM, XRD, and TGA. The antibacterial activity was shown by these polymer composites of piperic acid against Gram-positive Staphylococcus aureus (S. aureus-ATCC8738P) and Gram-negative Escherichia coli (E. coli-ATCC8739) was worthwhile. The antifungal activity of the composite films was evaluated by the food poisoning technique. Percentage mycelial growth inhibition was found maximum against Fusarium solani than Aspergillus and Penicillium. The water vapour and oxygen barrier properties are enhanced with the incorporation of increased content of piperic acid. Also, enhancement in the tensile strength of PVA/PA composite film was observed, while elongation at break shows decreased trend with the addition of piperic acid. The surface properties of polymer composite films were determined by contact angle measurements. Contact angle shows a considerable increase in these films when compared to virgin PVA film. It was increased by 56.1° in 15 mL composite film containing a higher concentration of piperic acid than virgin PVA.
胡椒酸是一种基于天然产物的衍生物，首次与聚乙烯醇一起用于形成聚合物复合膜，以对其进行合适的物理化学和抗菌性能改性。最初，胡椒酸由胡椒碱合成，胡椒碱是从黑胡椒（Piper nigrum）中提取的一种天然生物碱。采用溶液浇铸法合成聚乙烯醇 - 胡椒酸复合膜。通过紫外可见光谱、傅里叶变换红外光谱、扫描电子显微镜、X射线衍射和热重分析等各种光谱和显微镜技术对薄膜进行表征。这些胡椒酸聚合物复合材料对革兰氏阳性金黄色葡萄球菌（S. aureus - ATCC8738P）和革兰氏阴性大肠杆菌（E. coli - ATCC8739）表现出的抗菌活性值得关注。通过食物中毒技术评估复合膜的抗真菌活性。发现对茄病镰刀菌的菌丝体生长抑制百分比比对曲霉和青霉的抑制率更高。随着胡椒酸含量的增加，水蒸气和氧气阻隔性能得到增强。此外，观察到聚乙烯醇/胡椒酸复合膜的拉伸强度有所提高，而断裂伸长率随着胡椒酸的添加呈下降趋势。通过接触角测量确定聚合物复合膜的表面性能。与原始聚乙烯醇膜相比，这些膜的接触角有显著增加。在含有比原始聚乙烯醇更高浓度胡椒酸的15 mL复合膜中，接触角增加了56.1°。
