Malaria Branch, Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia.
Oak Ridge Associated Universities, Oak Ridge, Tennessee.
Am J Trop Med Hyg. 2022 Jun 15;106(6):1667-1669. doi: 10.4269/ajtmh.22-0073.
Sierra Leone relies heavily on histidine-rich protein 2-based diagnostics for malaria because of the high transmission of Plasmodium falciparum. During the 2015 recombinant vesicular stomatitis virus (VSV)-Zaire Ebola virus envelope glycoprotein (GP) vaccine trial, 77 participants with asymptomatic Plasmodium infection were enrolled, with all but four having P. falciparum malaria. Of the 73 participants with P. falciparum malaria, one infection (1 of 73, 1.4%; 95% CI, 0.03-7.4) showed P. falciparum with a pfhrp3 single deletion, and two P. falciparum infections (2 of 73, 2.7%; 95% CI, 0.03-9.6) showed pfhrp2/pfhrp3 dual deletions. This study shows evidence of pfhrp2- and pfhrp3-deleted parasites in Freetown, Sierra Leone. Additional studies for more precise estimates of prevalence are warranted.
塞拉利昂严重依赖富含组氨酸蛋白 2 的疟疾诊断方法，因为恶性疟原虫传播率很高。在 2015 年重组水疱性口炎病毒（VSV）-扎伊尔埃博拉病毒包膜糖蛋白（GP）疫苗试验中，招募了 77 名无症状疟原虫感染的参与者，除 4 人外均患有恶性疟。在 73 名患有恶性疟的参与者中，1 例感染（73 例中的 1 例，1.4%；95%CI，0.03-7.4）显示恶性疟原虫存在 pfhrp3 单一缺失，2 例恶性疟感染（73 例中的 2 例，2.7%；95%CI，0.03-9.6）显示 pfhrp2/pfhrp3 双重缺失。本研究表明在塞拉利昂弗里敦存在 pfhrp2 和 pfhrp3 缺失的疟原虫。需要进一步研究以更准确地估计流行率。
