Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS.
Department of Veterinary Medicine and Epidemiology, UC Davis School of Veterinary Medicine, Davis, CA.
Am J Vet Res. 2022 Jul 11;83(9):ajvr.21.11.0193. doi: 10.2460/ajvr.21.11.0193.
To evaluate and compare the anesthetic effects of alfaxalone-ketamine-midazolam (AKM) and alfaxalone-ketamine-dexmedetomidine (AKD) in black-tailed prairie dogs (Cynomys ludovicianus).
9 male black-tailed prairie dogs.
Prairie dogs were anesthetized with AKM (6 mg/kg alfaxalone, 30 mg/kg ketamine, and 1.5 mg/kg midazolam) and AKD (6 mg/kg alfaxalone, 30 mg/kg ketamine, and 0.15 mg/kg dexmedetomidine) in a prospective, complete cross-over study. Atipamezole (1.5 mg/kg) after AKD or flumazenil (0.1mg/kg) after AKM was administered 45 minutes after induction of anesthesia. Onset of general anesthesia, physiologic parameters, depth of anesthesia, and time to recovery after reversal administration were evaluated for each treatment.
Both AKM and AKD produced a deep plane of anesthesia in black-tailed prairie dogs that varied in duration. The median induction times for AKM and AKD were 82 and 60 seconds, respectively. The median recovery times for AKM and AKD were 27 and 21 minutes, respectively. There were no significant differences between protocols for induction (P = .37) and recovery (P = .51) times. All measured reflexes were absent in all animals at 5 minutes postinduction, with hindlimb reflexes returning prior to forelimb reflexes. Heart rate was lower but respiratory rate was higher in the AKD treatment. Body temperature decreased significantly for both protocols (P < .001) and was significantly lower with AKM than AKD (P < .001).
Both AKM and AKD produced a deep plane of anesthesia in black-tailed prairie dogs. For both protocols, heat support and oxygen support are indicated.
评估和比较氟烷-氯胺酮-咪达唑仑（AKM）和氟烷-氯胺酮-右美托咪定（AKD）在黑尾草原犬鼠中的麻醉效果。
9 只雄性黑尾草原犬鼠。
草原犬鼠接受 AKM（6mg/kg 氟烷、30mg/kg 氯胺酮和 1.5mg/kg 咪达唑仑）和 AKD（6mg/kg 氟烷、30mg/kg 氯胺酮和 0.15mg/kg 右美托咪定）麻醉，在一项前瞻性、完全交叉研究中。在诱导麻醉后 45 分钟，AKD 后给予阿替美唑（1.5mg/kg）或 AKM 后给予氟马西尼（0.1mg/kg）。评估每种治疗方法的全身麻醉起始时间、生理参数、麻醉深度和逆转后恢复时间。
AKM 和 AKD 均使黑尾草原犬鼠产生持续时间不同的深度麻醉平面。AKM 和 AKD 的中位诱导时间分别为 82 和 60 秒。AKM 和 AKD 的中位恢复时间分别为 27 和 21 分钟。两种方案的诱导（P=.37）和恢复（P=.51）时间均无显著差异。所有动物在诱导后 5 分钟时所有反射均消失，后肢反射先于前肢反射恢复。AKD 治疗组的心率较低，但呼吸频率较高。两种方案的体温均显著下降（P<0.001），AKM 组的体温明显低于 AKD 组（P<0.001）。
AKM 和 AKD 均使黑尾草原犬鼠产生深度麻醉平面。对于两种方案，都需要提供热支持和氧支持。
