Guangdong Provincial Engineering Technology Research Center for Drug and Food Biological Resources Processing and Comprehensive Utilization, School of Life Sciences, South China Normal University, Guangzhou, China.
Guangzhou Quality Supervision and Testing Institute, Guangzhou, China.
J Environ Sci Health C Toxicol Carcinog. 2022;40(2):154-171. doi: 10.1080/26896583.2022.2062199. Epub 2022 Jun 6.
Chronic exposure to polycyclic aromatic hydrocarbons (PAHs) leads to a high incidence of cardiovascular diseases. To assess the effects of PAHs exposure on vascular damages in occupationally exposed populations, 196 sanitation workers were recruited. According to the differences of occupation or operation, they were divided into exposure group (n = 115) and control group (n = 81). Sixteen serum PAHs were determined by gas chromatography-tandem mass spectrometery. Tumor necrosis factor ɑ (TNF-ɑ) and angiotensin II (ANG-II) in serum, blood lipids and blood pressure were also measured. Results showed that, except for indeno(1,2,3-cd)pyrene, dibenzo(a,h)anthracene and benzo(g,h,i)perylene, the detection frequencies of other PAHs were above 85%, showing that subjects are generally exposed to PAHs. The top three compounds in serum concentrations of PAHs were phenanthrene, acenaphthylene and anthracene. Moreover, the concentrations of total serum PAHs in the exposure group were significantly higher than those in the control ( < 0.05), suggesting a higher PAHs exposure in the former. Though there was no significant difference in blood lipids and blood pressure between groups ( > 0.05), TNF-ɑ and ANG-II levels in the exposure group were significantly higher than those in the control group ( < 0.05), suggesting that PAHs exposure may be related to pro-inflammatory effects and vascular endothelial damages.
慢性暴露于多环芳烃（PAHs）会导致心血管疾病的高发。为了评估 PAHs 暴露对职业暴露人群血管损伤的影响，招募了 196 名环卫工人。根据职业或操作的不同，将他们分为暴露组（n=115）和对照组（n=81）。采用气相色谱-串联质谱法测定了 16 种血清 PAHs。还测量了血清中的肿瘤坏死因子 α（TNF-α）和血管紧张素 II（ANG-II）、血脂和血压。结果表明，除了茚并（1,2,3-cd）芘、二苯并（a,h）蒽和苯并（g,h,i）苝外，其他 PAHs 的检测频率均高于 85%，表明研究对象普遍受到 PAHs 的暴露。血清中 PAHs 浓度最高的三种化合物是菲、苊烯和蒽。此外，暴露组的总血清 PAHs 浓度明显高于对照组（<0.05），提示前者的 PAHs 暴露水平更高。尽管两组之间的血脂和血压无显著差异（>0.05），但暴露组的 TNF-α和 ANG-II 水平明显高于对照组（<0.05），提示 PAHs 暴露可能与促炎作用和血管内皮损伤有关。
