Laboratory of Veterinary Physiology, School of Veterinary Medicine, Kitasato University, Aomori, Japan.
Division of Companion Animal Medicine, Faculty of Veterinary Medicine, Khon Kaen University, Khon Kaen, Thailand.
J Vet Med Sci. 2022 Sep 12;84(9):1288-1291. doi: 10.1292/jvms.22-0272. Epub 2022 Jul 26.
The expression of annexin A1 (ANXA1) is augmented by gonadotrophin releasing hormone (GnRH) in LβT2 gonadotroph. We examined the distribution of ANXA1 in the pituitary tissues and the effect of ovariectomy. ANXA1 was mainly stained on folliculostellate cell-like irregular shaped cells with extended process of adult female rats. Large gonadotroph, so called castration cells, appeared two weeks after the ovariectomy. ANXA1 in castration cells exists around cells although another GnRH responsive annexin, ANXA5, was apparent also in the cytoplasm. The pituitary expression of ANXA1 after ovariectomy was significantly higher than intact rats. These difference in tissue distribution of two annexins suggest ANXA1 and ANXA5 bear different physiological function in the gonadotroph under GnRH regulation.
促性腺激素释放激素（GnRH）可增强黄体生成素细胞（LβT2 细胞）中膜联蛋白 A1（ANXA1）的表达。我们检测了 ANXA1 在垂体组织中的分布以及卵巢切除术的影响。成年雌性大鼠的垂体组织中，ANXA1 主要存在于卵泡星状细胞样的异形细胞上，这些细胞具有延伸的突起。卵巢切除后两周，出现了大的促性腺细胞，即去势细胞。尽管另一种 GnRH 反应性的膜联蛋白 ANXA5 也存在于细胞质中，但去势细胞中的 ANXA1 存在于细胞周围。卵巢切除后，垂体中 ANXA1 的表达明显高于完整大鼠。这两种膜联蛋白在组织分布上的差异表明，在 GnRH 调节下，ANXA1 和 ANXA5 在促性腺细胞中具有不同的生理功能。
