[Clinical characteristics of biliary obstruction patients with infections].

OBJECTIVE

To analyze the clinical characteristics of biliary obstruction patients with infections, so as to provide insights into the clinical diagnosis and therapy of this comorbidity.

METHODS

A total of 45 biliary obstruction patients with infections that were admitted to the Second Affiliated Hospital of Harbin Medical University from October 2012 to September 2019 were enrolled, and 45 patients with biliary obstruction alone at the hospital during the same study period were recruited as controls. Univariate analysis was performed to analyze the epidemiological characteristics, clinical manifestations, laboratory examination results and imaging manifestations related to infection, and the statistically significant univariate was used as an independent variable for multivariate logistic regression analysis.

RESULTS

Compared with biliary obstruction alone, males (91.11% vs. 46.67%; = 20.737, < 0.01) and rural areas (62.22% vs. 22.22%; = 14.757, < 0.01) showed a significantly higher proportion in biliary obstruction patients with infections. The major clinical symptoms involved in had jaundice (45 cases, 100%) and abdominal pain (40 cases, 88.89%) in -infected patients. Logistic regression analysis showed that males [odds ratio () = 10.717, 95% confidential interval (): (2.571, 44.662)] and drinking alcohol [ = 4.474, 95% : (1.019, 19.642)] were risk factors for biliary obstruction patients with infections, while living in city [ = 0.128, 95% : (0.038, 0.435)] was a protective factor. Additionally, in biliary obstruction patients with infections, lower total bilirubin ( = -2.566, <0.05) and direct bilirubin ( = -3.454, <0.05), higher indirect bilirubin ( = -3.821, < 0.05), thickening of the bile duct wall and dilatation of the intrahepatic bile duct were detected.

CONCLUSIONS

A comprehensive diagnosis requires to be made based on clinical symptoms, laboratory and imaging examinations, in order to improve the diagnosis of biliary obstruction patients with infections.