Food Packaging Forum Foundation, 8045 Zürich, Switzerland.
Department of Environmental Systems Science, ETH Zürich, 8092 Zürich, Switzerland.
J Hazard Mater. 2022 Sep 5;437:129167. doi: 10.1016/j.jhazmat.2022.129167. Epub 2022 May 20.
The EU Chemicals Strategy for Sustainability (CSS) aims at removing the most harmful chemicals from consumer products, including from food contact materials (FCMs). If implemented as intended, the CSS has the potential to significantly improve the protection of public health by banning the use of chemicals of concern that are carcinogenic, mutagenic, or toxic to reproduction (CMRs), or persistent and bioaccumulative, or endocrine-disrupting chemicals (EDCs) in FCMs. However, until now an overview of such food contact chemicals of concern (FCCoCs) has not been available, because the CSS is fairly recent. Therefore, we here systematically analyze the food contact chemicals listed for intentional use in FCMs and identify known FCCoCs. We present a list of 388 FCCoCs that should be phased-out from use. Of these, 352 are CMRs, four are per- and polyfluoroalkyl substances (PFAS), and 127 have empirical evidence for presence in FCMs. Importantly, 30 FCCoCs with evidence for presence are monomers of which 22 have evidence for migration into foodstuff showing that monomers in FCMs indeed become relevant for human exposure. Our findings justify moving away from a risk- towards a hazard-based approach to regulation of chemicals in FCMs.
欧盟可持续性化学品战略（CSS）旨在从消费品中去除最有害的化学物质，包括食品接触材料（FCM）。如果按计划实施，CSS 有可能通过禁止在 FCM 中使用致癌、致突变、对生殖有毒的或持久性和生物累积性的或内分泌干扰性化学物质（CMR 和 EDC），从而显著改善对公众健康的保护。然而，到目前为止，还没有关于此类食品接触化学物质的概述，因为 CSS 是相当新的。因此，我们在这里系统地分析了 FCM 中有意使用的食品接触化学物质，并确定了已知的 FCCoCs。我们列出了 388 种应逐步淘汰的 FCCoCs。其中，352 种是 CMR，4 种是全氟和多氟烷基物质（PFAS），127 种有在 FCMs 中存在的经验证据。重要的是，有存在证据的 30 种 FCCoCs 是单体，其中 22 种有证据表明单体迁移到食品中，这表明 FCMs 中的单体确实与人类暴露有关。我们的发现证明了从基于风险的方法向基于危害的方法转移对 FCM 中化学物质的监管是合理的。
