Department of Obstetrics and Gynaecology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, Bandar Tun Razak, Cheras, Kuala Lumpur 5600, Malaysia.
Department of Pathology, Hospital Melaka, Jalan Mufti Haji Khalil, Melaka 75400, Malaysia.
Int J Environ Res Public Health. 2022 Jul 25;19(15):9059. doi: 10.3390/ijerph19159059.
Endometrial cancer is the sixth most common malignancy in women, and it is known to be a disease among postmenopausal women, but there is rising in the number of endometrial cancers among premenopausal women. This study aims to determine the clinical characteristic, risk factors, outcomes, and survival in pre and postmenopausal women with endometrial cancer in Malaysia. A retrospective study was conducted in Hospital Melaka that involved all women who were diagnosed with endometrial cancer in Hospital Melaka from January 2002 until July 2020. All subjects' histopathological examination result was confirmed, and their clinical data were extracted and transferred into a standardized data checklist and analysed. A total number of 392 cases was obtained from the Annual Cancer Registry Hospital Melaka. However, only 281 cases were studied, including 44.8% premenopausal and 55.2% postmenopausal women. In the premenopausal group, there were higher incidence of obesity (30.8 + 8.6 vs. 28.9 + 7.1), younger age at menarche (12.7 + 1.5 vs. 13.3 + 1.6), lesser parity (1.47 vs. 3.26), and a higher number of nulliparous women (46.8% vs. 19.4%) as compared to postmenopausal group. The premenopausal group tends to be presented with a well-differentiated grading of tumour (52.4%) and a higher incidence of having concomitant endometrial hyperplasia (41.3%). The mean survival among the premenopausal group (200.3 + 7.9 months) is higher compared to postmenopausal group (153.9 + 6.5 months). These findings correlate with good survival and prognosis among the premenopausal group compared to the postmenopausal group.
子宫内膜癌是女性中第六种最常见的恶性肿瘤，已知是绝经后妇女的一种疾病，但绝经前妇女的子宫内膜癌数量正在增加。本研究旨在确定马来西亚绝经前和绝经后妇女子宫内膜癌的临床特征、危险因素、结局和生存率。这项回顾性研究在马六甲医院进行，涉及所有在马六甲医院被诊断为子宫内膜癌的女性，时间为 2002 年 1 月至 2020 年 7 月。所有患者的组织病理学检查结果均得到证实，并提取和转移其临床数据到标准化数据检查表中进行分析。从马六甲年度癌症登记处获得了 392 例病例。然而，仅对 281 例进行了研究，包括 44.8%的绝经前和 55.2%的绝经后妇女。在绝经前组中，肥胖发生率更高（30.8+8.6 比 28.9+7.1），初潮年龄更小（12.7+1.5 比 13.3+1.6），生育次数更少（1.47 比 3.26），未生育的女性更多（46.8%比 19.4%）。与绝经后组相比，绝经前组的肿瘤分级分化程度更高（52.4%），同时患有子宫内膜增生的发生率更高（41.3%）。绝经前组的平均生存时间（200.3+7.9 个月）高于绝经后组（153.9+6.5 个月）。这些发现与绝经前组比绝经后组有更好的生存和预后相关。
