Yasumizu T, Ogawa K, Kato J
Department of Obstetrics and Gynecology, Yamanashi Medical University, Japan.
Jpn J Clin Oncol. 1996 Jun;26(3):152-6. doi: 10.1093/oxfordjournals.jjco.a023199.
A study was performed to clarify the clinicopathological differences between premenopausal endometrial carcinoma, which occurs during the reproductive period, and postmenopausal endometrial carcinoma. We analyzed 76 patients with endometrial carcinoma treated in our department between January 1984 and July 1994. Using classification criteria which included menstrual history and results of endocrinological tests (serum FSH, LH and estradiol), 50 (65.7%) patients were defined as postmenopausal, 16 (21.0%) as premenopausal, and 10 (13.1%) as unclassified. From an epidemiologic viewpoint, the incidence of nulliparity was higher in the premenopausal (37.5%) than in the postmenopausal (10%) patients. However, no significant differences were observed between the two groups with regard to the incidence of obesity, diabetes and hypertension. The results of our clinicopathological study revealed that premenopausal endometrial carcinoma had a significantly higher incidence of well differentiated (63.1%) and relatively less advanced (31.1% of cases at stages III and IV) cancers than postmenopausal carcinoma (38% and 46%, respectively). These features were positively correlated with prognosis, i.e., premenopausal patients in general had a much better prognosis than postmenopausal patients.
开展了一项研究，以阐明生育期发生的绝经前子宫内膜癌与绝经后子宫内膜癌之间的临床病理差异。我们分析了1984年1月至1994年7月间在我科接受治疗的76例子宫内膜癌患者。根据包括月经史和内分泌检查结果（血清促卵泡激素、促黄体生成素和雌二醇）在内的分类标准，50例（65.7%）患者被定义为绝经后，16例（21.0%）为绝经前，10例（13.1%）为未分类。从流行病学角度来看，绝经前患者（37.5%）未生育的发生率高于绝经后患者（10%）。然而，两组在肥胖、糖尿病和高血压的发生率方面未观察到显著差异。我们的临床病理研究结果显示，绝经前子宫内膜癌高分化癌的发生率（63.1%）显著高于绝经后癌（38%），且相对晚期癌症的发生率较低（III期和IV期病例分别为31.1%）。这些特征与预后呈正相关，即一般而言，绝经前患者的预后比绝经后患者好得多。
