School of Physics, East China University of Science and Technology, Shanghai 200237, China.
Interdisciplinary Research Center, Shanghai Synchrotron Radiation Facility, Zhangjiang Laboratory (SSRF, ZJLab), Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201204, China.
Int J Mol Sci. 2022 Jul 22;23(15):8055. doi: 10.3390/ijms23158055.
Great efforts have been made to separate micro/nanoparticles in small-volume specimens, but it is a challenge to achieve the simple, maneuverable and low-cost separation of sub-microliter suspension with large separation distances. By simply adding trace amounts of cations (Mg/Ca/Na), we experimentally achieved the size-dependent spontaneous separation of colloidal particles in an evaporating droplet with a volume down to 0.2 μL. The separation distance was at a millimeter level, benefiting the subsequent processing of the specimen. Within only three separating cycles, the mass ratio between particles with diameters of 1.0 μm and 0.1 μm can be effectively increased to 13 times of its initial value. A theoretical analysis indicates that this spontaneous separation is attributed to the size-dependent adsorption between the colloidal particles and the aromatic substrate due to the strong hydrated cation-π interactions.
人们已经做出了巨大努力来分离小体积样本中的微/纳米颗粒，但要实现具有较大分离距离的亚微升悬浮液的简单、灵活且低成本的分离仍然是一个挑战。通过简单地添加痕量的阳离子（Mg/Ca/Na），我们在实验中实现了在体积降至 0.2 μL 的蒸发液滴中胶体颗粒的尺寸依赖性自发分离。分离距离在毫米级别，有利于随后对样品的处理。仅通过三个分离循环，直径为 1.0 μm 和 0.1 μm 的颗粒之间的质量比就可以有效增加到初始值的 13 倍。理论分析表明，这种自发分离归因于胶体颗粒和芳香基质之间的尺寸依赖性吸附，这是由于强水合阳离子-π 相互作用。
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